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Endocervical Adenocarcinoma In Situ

Endocervical Adenocarcinoma In Situ International Journal of Gynecological Pathology 28:140–141, Lippincott Williams & Wilkins, Baltimore r 2009 International Society of Gynecological Pathologists Letter to the Editor Serous Type To the Editor: Endocervical adenocarcinoma in situ (AIS) is a precursor to invasive endocervical adenocarcinoma. Several subtypes of AIS have been described; the most commonly recognized are endocervical and intestinal types followed by endometrioid, tubal, and stratified (adenosquamous) types (1–3). Immu- nohistochemically, AIS is characterized by high ki-67 index and diffuse p16 immunoreactivity (4). Serous carcinoma of the uterine cervix is a rare type of invasive endocervical adenocarcinoma with morpho- logic features indistinguishable from its endometrial FIG. 2. Hematoxylin and eosin stain (high power). In situ adenocarcinoma featuring oval enlarged nuclei with coarse counterpart (5,6). Endocervical serous carcinoma chromatin and occasional prominent nucleoli. differs from conventional types of endocervical adenocarcinoma cytoarchitecturally, immunohisto- chemically, and prognostically (7). However, its We have recently encountered a case of endocervi- pathogenesis and possible association with human cal serous carcinoma diagnosed in a 62-year-old papillomavirus infection is yet to be established. woman who underwent radical hysterectomy, bilat- Unlike the case with conventional types of endocer- eral salpingo-oophorectomy, and pelvic lymphade- vical adenocarcinoma, to the best of our knowledge, nectomy. The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Gynecological Pathology Wolters Kluwer Health

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ISSN
0277-1691
eISSN
1538-7151
DOI
10.1097/PGP.0b013e31818e30f6
pmid
19188821
Publisher site
See Article on Publisher Site

Abstract

International Journal of Gynecological Pathology 28:140–141, Lippincott Williams & Wilkins, Baltimore r 2009 International Society of Gynecological Pathologists Letter to the Editor Serous Type To the Editor: Endocervical adenocarcinoma in situ (AIS) is a precursor to invasive endocervical adenocarcinoma. Several subtypes of AIS have been described; the most commonly recognized are endocervical and intestinal types followed by endometrioid, tubal, and stratified (adenosquamous) types (1–3). Immu- nohistochemically, AIS is characterized by high ki-67 index and diffuse p16 immunoreactivity (4). Serous carcinoma of the uterine cervix is a rare type of invasive endocervical adenocarcinoma with morpho- logic features indistinguishable from its endometrial FIG. 2. Hematoxylin and eosin stain (high power). In situ adenocarcinoma featuring oval enlarged nuclei with coarse counterpart (5,6). Endocervical serous carcinoma chromatin and occasional prominent nucleoli. differs from conventional types of endocervical adenocarcinoma cytoarchitecturally, immunohisto- chemically, and prognostically (7). However, its We have recently encountered a case of endocervi- pathogenesis and possible association with human cal serous carcinoma diagnosed in a 62-year-old papillomavirus infection is yet to be established. woman who underwent radical hysterectomy, bilat- Unlike the case with conventional types of endocer- eral salpingo-oophorectomy, and pelvic lymphade- vical adenocarcinoma, to the best of our knowledge, nectomy. The

Journal

International Journal of Gynecological PathologyWolters Kluwer Health

Published: Mar 1, 2009

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