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Endocervical Adenocarcinomas With Prominent Endometrial or Endomyometrial Involvement Simulating Primary Endometrial Carcinomas Utility of HPV DNA Detection and Immunohistochemical Expression of p16 and Hormone Receptors to Confirm the Cervical Origin of the Corpus Tumor

Endocervical Adenocarcinomas With Prominent Endometrial or Endomyometrial Involvement Simulating... ORIGINAL ARTICLE Endocervical Adenocarcinomas With Prominent Endometrial or Endomyometrial Involvement Simulating Primary Endometrial Carcinomas Utility of HPV DNA Detection and Immunohistochemical Expression of p16 and Hormone Receptors to Confirm the Cervical Origin of the Corpus Tumor Anna Yemelyanova, MD,* Russell Vang, MD,*w Jeffrey D. Seidman, MD,z Patti E. Gravitt, PhD,y and Brigitte M. Ronnett, MD*w decreased or absent expression of hormone receptors. These Abstract: Determining the primary site of a uterine adenocarci- ancillary techniques are useful for clarifying the origin of uterine noma can be problematic in hysterectomy specimens due to the adenocarcinomas when morphologic features and tumor loca- overlapping morphology of endocervical adenocarcinomas tion are equivocal. These cases illustrate that dominant uterine and endometrial carcinomas, particularly when both the corpus corpus involvement (endometrial or endomyometrial) by (usually lower uterine segment) and endocervix are involved and primary endocervical adenocarcinoma can lead to misclassifica- precursor lesions are lacking or difficult to distinguish from tion as primary endometrial adenocarcinoma with cervical intramucosal spread of carcinoma from one site to the other. extension (Fe´ de´ ration Internationale de Gyne´ cologie et Both preferential extension of endocervical adenocarcinomas d’Obste´ trique stage II), especially when endometrial extension into the endometrium (rather than deep cervical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Surgical Pathology Wolters Kluwer Health

Endocervical Adenocarcinomas With Prominent Endometrial or Endomyometrial Involvement Simulating Primary Endometrial Carcinomas Utility of HPV DNA Detection and Immunohistochemical Expression of p16 and Hormone Receptors to Confirm the Cervical Origin of the Corpus Tumor

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References (51)

ISSN
0147-5185
eISSN
1532-0979
DOI
10.1097/PAS.0b013e3181971fdd
pmid
19295407
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Endocervical Adenocarcinomas With Prominent Endometrial or Endomyometrial Involvement Simulating Primary Endometrial Carcinomas Utility of HPV DNA Detection and Immunohistochemical Expression of p16 and Hormone Receptors to Confirm the Cervical Origin of the Corpus Tumor Anna Yemelyanova, MD,* Russell Vang, MD,*w Jeffrey D. Seidman, MD,z Patti E. Gravitt, PhD,y and Brigitte M. Ronnett, MD*w decreased or absent expression of hormone receptors. These Abstract: Determining the primary site of a uterine adenocarci- ancillary techniques are useful for clarifying the origin of uterine noma can be problematic in hysterectomy specimens due to the adenocarcinomas when morphologic features and tumor loca- overlapping morphology of endocervical adenocarcinomas tion are equivocal. These cases illustrate that dominant uterine and endometrial carcinomas, particularly when both the corpus corpus involvement (endometrial or endomyometrial) by (usually lower uterine segment) and endocervix are involved and primary endocervical adenocarcinoma can lead to misclassifica- precursor lesions are lacking or difficult to distinguish from tion as primary endometrial adenocarcinoma with cervical intramucosal spread of carcinoma from one site to the other. extension (Fe´ de´ ration Internationale de Gyne´ cologie et Both preferential extension of endocervical adenocarcinomas d’Obste´ trique stage II), especially when endometrial extension into the endometrium (rather than deep cervical

Journal

American Journal of Surgical PathologyWolters Kluwer Health

Published: Jun 1, 2009

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