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Evaluation of Kras

Evaluation of Kras ORIGINAL ARTICLE Evaluation of Kras Gene Mutation and Copy Number Gain in Non-small Cell Lung Cancer Hidefumi Sasaki, MD, PhD, Yu Hikosaka, MD, PhD, Osamu Kawano, MD, PhD, Satoru Moriyama, MD, PhD, Motoki Yano, MD, PhD, and Yoshitaka Fujii, MD, PhD studies in cell lines and murine models established the pos- Introduction: Recent studies for the characterization of the lung sibility that amplification of wild-type Ras genes could lead cancer genome have suggested that Kras gene was frequently 5,6 to malignant transformation. Recent studies using low- amplified and correlated with activating mutations of Kras, which resolution, conventional comparative genome hybridization occur in approximately 5 to 10% of Japanese lung cancers. have identified frequent copy number gains of the 12p12. 1 Methods: We analyzed Kras mutation and Kras copy number in 7–11 region, including Kras from several cancers. Moreover, in 172 Japanese non-small cell lung cancer (NSCLC) cases and their recent large-scale systematic assessments of the lung adeno- relation to the survival of patients. We also studied using fluores- carcinoma genome, analysis of single-nucleotide polymor- cence in situ hybridization to provide direct evidence of Kras phism arrays has identified Kras copy number gains as one of amplification in 40 clinical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Evaluation of Kras

Fujii, Yoshitaka
Journal of Thoracic Oncology , Volume 6 (1) – Jan 1, 2011
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ISSN
1556-0864
DOI
10.1097/JTO.0b013e31820594f0
pmid
21150464
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Evaluation of Kras Gene Mutation and Copy Number Gain in Non-small Cell Lung Cancer Hidefumi Sasaki, MD, PhD, Yu Hikosaka, MD, PhD, Osamu Kawano, MD, PhD, Satoru Moriyama, MD, PhD, Motoki Yano, MD, PhD, and Yoshitaka Fujii, MD, PhD studies in cell lines and murine models established the pos- Introduction: Recent studies for the characterization of the lung sibility that amplification of wild-type Ras genes could lead cancer genome have suggested that Kras gene was frequently 5,6 to malignant transformation. Recent studies using low- amplified and correlated with activating mutations of Kras, which resolution, conventional comparative genome hybridization occur in approximately 5 to 10% of Japanese lung cancers. have identified frequent copy number gains of the 12p12. 1 Methods: We analyzed Kras mutation and Kras copy number in 7–11 region, including Kras from several cancers. Moreover, in 172 Japanese non-small cell lung cancer (NSCLC) cases and their recent large-scale systematic assessments of the lung adeno- relation to the survival of patients. We also studied using fluores- carcinoma genome, analysis of single-nucleotide polymor- cence in situ hybridization to provide direct evidence of Kras phism arrays has identified Kras copy number gains as one of amplification in 40 clinical

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Jan 1, 2011

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