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Gastrointestinal Stromal Tumor of the Uterus: A Case Report With Genetic Analyses of c-kit and PDGFRA Genes

Gastrointestinal Stromal Tumor of the Uterus: A Case Report With Genetic Analyses of c-kit... International Journal of Gynecological Pathology 28:29–34, Lippincott Williams & Wilkins, Baltimore r 2008 International Society of Gynecological Pathologists Case Report Gastrointestinal Stromal Tumor of the Uterus: A Case Report With Genetic Analyses of c-kit and PDGFRA Genes Tadashi Terada, M.D., Ph.D. Summary: The author reports a very rare case of a gastrointestinal stromal tumor in the uterus. A 74-year-old woman was admitted to our hospital because of pelvic pain. Imaging modalities showed a large tumor of the posterior aspect of the uterus, and enucleation was performed. The tumor was attached to the posterior uterus, similar to subserosal leiomyoma. No attachment to the gastrointestinal organs was recognized. The tumor was soft, tan, and measured 13  15  12 cm. The tumor consisted of cellular spindle cells with focal necrotic areas. Mitotic figures were noted in 3 of 50 high-power fields. The tumor cells were positive for KIT, CD34, platelet-derived growth factor receptor a, and vimentin, but negative for a-smooth muscle actin, S100 protein, p53 protein, HMB45, and desmin. Ki-67 labeling was 3%. Five normal uteruses used as controls showed KIT-positive Cajal-like mesenchymal cell scattering in the myome- trium. Genetic analyses of the c-kit gene (exons 9, 11, 13, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Gynecological Pathology Wolters Kluwer Health

Gastrointestinal Stromal Tumor of the Uterus: A Case Report With Genetic Analyses of c-kit and PDGFRA Genes

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ISSN
0277-1691
eISSN
1538-7151
DOI
10.1097/PGP.0b013e3181808000
pmid
19047911
Publisher site
See Article on Publisher Site

Abstract

International Journal of Gynecological Pathology 28:29–34, Lippincott Williams & Wilkins, Baltimore r 2008 International Society of Gynecological Pathologists Case Report Gastrointestinal Stromal Tumor of the Uterus: A Case Report With Genetic Analyses of c-kit and PDGFRA Genes Tadashi Terada, M.D., Ph.D. Summary: The author reports a very rare case of a gastrointestinal stromal tumor in the uterus. A 74-year-old woman was admitted to our hospital because of pelvic pain. Imaging modalities showed a large tumor of the posterior aspect of the uterus, and enucleation was performed. The tumor was attached to the posterior uterus, similar to subserosal leiomyoma. No attachment to the gastrointestinal organs was recognized. The tumor was soft, tan, and measured 13  15  12 cm. The tumor consisted of cellular spindle cells with focal necrotic areas. Mitotic figures were noted in 3 of 50 high-power fields. The tumor cells were positive for KIT, CD34, platelet-derived growth factor receptor a, and vimentin, but negative for a-smooth muscle actin, S100 protein, p53 protein, HMB45, and desmin. Ki-67 labeling was 3%. Five normal uteruses used as controls showed KIT-positive Cajal-like mesenchymal cell scattering in the myome- trium. Genetic analyses of the c-kit gene (exons 9, 11, 13, and

Journal

International Journal of Gynecological PathologyWolters Kluwer Health

Published: Jan 1, 2009

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