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Generation and Sequencing of Pulmonary Carcinoid Tumor Cell Lines

Generation and Sequencing of Pulmonary Carcinoid Tumor Cell Lines Original Atricle Generation and Sequencing of Pulmonary Carcinoid  Tumor Cell Lines Michael K. Asiedu, PhD,* Charles F. Thomas, Jr., MD,† Sandra C. Tomaszek, MD,* Tobias Peikert, MD,† Bharati Sanyal, PhD,†Shari L. Sutor, MS,* Marie-Christine Aubry, MD,‡ Peter Li, PhD,§ and Dennis A. Wigle* ulmonary carcinoid tumors represent a subset of up to 5% Introduction: Pulmonary carcinoid tumors account for approxi- 1,2 Pof all primary bronchopulmonary neoplasms. Their inci- mately 5% of all lung malignancies in adults, and comprise 30% of dence has rapidly increased within the past 30 years, and was all carcinoid tumors. There are limited reagents available to study 1.57 per 100,000 in 2003 . Overall, carcinoid tumors may be these rare tumors, and consequently no major advances have been found elsewhere in the body, most commonly in the appen- made for patient treatment. We report the generation and charac- dix, followed by rectum, ileum, lungs, bronchi, and stomach. terization of human pulmonary carcinoid tumor cell lines to study Pulmonary carcinoid tumors are thought to arise from the neu- underlying biology, and to provide models for testing novel chemo- roendocrine cells of the bronchopulmonary epithelium. therapeutic agents. The 2004 World Health Organization classification of Methods: Tissue was harvested from three patients with primary lung http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Generation and Sequencing of Pulmonary Carcinoid Tumor Cell Lines

Wigle, Dennis A.
Journal of Thoracic Oncology , Volume 9 (12) – Dec 1, 2014
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Copyright
Copyright © 2014 by the International Association for the Study of Lung Cancer
ISSN
1556-0864

Abstract

Original Atricle Generation and Sequencing of Pulmonary Carcinoid  Tumor Cell Lines Michael K. Asiedu, PhD,* Charles F. Thomas, Jr., MD,† Sandra C. Tomaszek, MD,* Tobias Peikert, MD,† Bharati Sanyal, PhD,†Shari L. Sutor, MS,* Marie-Christine Aubry, MD,‡ Peter Li, PhD,§ and Dennis A. Wigle* ulmonary carcinoid tumors represent a subset of up to 5% Introduction: Pulmonary carcinoid tumors account for approxi- 1,2 Pof all primary bronchopulmonary neoplasms. Their inci- mately 5% of all lung malignancies in adults, and comprise 30% of dence has rapidly increased within the past 30 years, and was all carcinoid tumors. There are limited reagents available to study 1.57 per 100,000 in 2003 . Overall, carcinoid tumors may be these rare tumors, and consequently no major advances have been found elsewhere in the body, most commonly in the appen- made for patient treatment. We report the generation and charac- dix, followed by rectum, ileum, lungs, bronchi, and stomach. terization of human pulmonary carcinoid tumor cell lines to study Pulmonary carcinoid tumors are thought to arise from the neu- underlying biology, and to provide models for testing novel chemo- roendocrine cells of the bronchopulmonary epithelium. therapeutic agents. The 2004 World Health Organization classification of Methods: Tissue was harvested from three patients with primary lung

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Dec 1, 2014

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