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GPC5

GPC5 PATHWAY OF THE MONTH GPC5 Gene and Its Related Pathways in Lung Cancer Yafei Li and Ping Yang based study reported a homozygous deletion at 13q31.3 in a Key Words: Lung cancer, Glypcian-5, Wnt, Hedgehog, Fibroblast non-small cell lung cancer cell line. Another array CGH- growth factors. based study recently analyzed a series of 14 patients with 13q (J Thorac Oncol. 2011;6: 2–5) partial deletion syndrome and noted lung hypoplasia as one of the common phenotypes. Among the 14 patients, two had lung hypoplasia. Amplification and overexpression of the ecently, a five-center collaborative study reported that ge- miR-17-92 miRNA cluster at 13q31.3 was recently reported Rnetic variations of glypican-5 (GPC5) may significantly in lung cancers from one study ; another study showed that contribute to an increased risk of lung cancer in never smokers. inhibition of miR-17-5p and miR-20a with antisense oligo- nucleotides can induce apoptosis selectively in lung cancer GPC5 gene expression levels in normal lung tissues were found cells overexpressing miR-17-92. When using TargetScan significantly lower in individuals who carry high-risk alleles, (http://www.targetscan.org/vert_50/) to predict biologic tar- and the GPC5 expression level in adenocarcinoma tissue was gets of miRNAs, miR-17, miR-20a, miR-20b, miR-23a, and significantly lower than http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

GPC5

Yang, Ping
Journal of Thoracic Oncology , Volume 6 (1) – Jan 1, 2011
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ISSN
1556-0864
DOI
10.1097/JTO.0b013e3181fd6b04
pmid
21178712
Publisher site
See Article on Publisher Site

Abstract

PATHWAY OF THE MONTH GPC5 Gene and Its Related Pathways in Lung Cancer Yafei Li and Ping Yang based study reported a homozygous deletion at 13q31.3 in a Key Words: Lung cancer, Glypcian-5, Wnt, Hedgehog, Fibroblast non-small cell lung cancer cell line. Another array CGH- growth factors. based study recently analyzed a series of 14 patients with 13q (J Thorac Oncol. 2011;6: 2–5) partial deletion syndrome and noted lung hypoplasia as one of the common phenotypes. Among the 14 patients, two had lung hypoplasia. Amplification and overexpression of the ecently, a five-center collaborative study reported that ge- miR-17-92 miRNA cluster at 13q31.3 was recently reported Rnetic variations of glypican-5 (GPC5) may significantly in lung cancers from one study ; another study showed that contribute to an increased risk of lung cancer in never smokers. inhibition of miR-17-5p and miR-20a with antisense oligo- nucleotides can induce apoptosis selectively in lung cancer GPC5 gene expression levels in normal lung tissues were found cells overexpressing miR-17-92. When using TargetScan significantly lower in individuals who carry high-risk alleles, (http://www.targetscan.org/vert_50/) to predict biologic tar- and the GPC5 expression level in adenocarcinoma tissue was gets of miRNAs, miR-17, miR-20a, miR-20b, miR-23a, and significantly lower than

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Jan 1, 2011

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