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High Incidence of EGFR Mutations in Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features

High Incidence of EGFR Mutations in Korean Men Smokers with No Intratumoral Heterogeneity of Lung... ORIGINAL ARTICLE High Incidence of EGFR Mutations in Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features Ping-Li Sun, MD,*† Hyesil Seol, MD,‡ Hyun Ju Lee, MD,§ Seol Bong Yoo, MD,* Hyojin Kim, MD,* Xianhua Xu, MD,* Sanghoon Jheon, MD, PhD,† Choon-Taek Lee, MD, PhD, Jong-Suk Lee, MD, PhD, and Jin-Haeng Chung, MD, PhD* EGFR mutations were more frequently observed in tumors with BAC Introduction: Epidermal growth factor receptor (EGFR) mutation or papillary components than those with mucinous BAC or solid has been known to be associated with adenocarcinoma with bron- components. Identical EGFR mutations were detected in a single tumor chioloalveolar carcinoma (BAC; lepidic) feature. This study was showing mixed histological features. EGFR protein expression was aimed to characterize the frequency of EGFR mutations and their seen more frequently in tumors with EGFR mutations than those without association with histologic subtypes in Korean nonsmall cell lung EGFR mutations (75.3% versus 24.7%, p 0.003). EGFR mutations were cancer (NSCLC) patients. significantly more common in tumors with thyroid transcription factor-1 Methods: Three hundred eighty-two (88 biopsies and 294 resec- (TTF-1) expression than those without TTF-1 (p  0.001), and almost http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

High Incidence of EGFR Mutations in Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features

Journal of Thoracic Oncology , Volume 7 (2) – Feb 1, 2012

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References (36)

Copyright
Copyright © 2012 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
DOI
10.1097/JTO.0b013e3182381515
pmid
22237264
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE High Incidence of EGFR Mutations in Korean Men Smokers with No Intratumoral Heterogeneity of Lung Adenocarcinomas Correlation with Histologic Subtypes, EGFR/TTF-1 Expressions, and Clinical Features Ping-Li Sun, MD,*† Hyesil Seol, MD,‡ Hyun Ju Lee, MD,§ Seol Bong Yoo, MD,* Hyojin Kim, MD,* Xianhua Xu, MD,* Sanghoon Jheon, MD, PhD,† Choon-Taek Lee, MD, PhD, Jong-Suk Lee, MD, PhD, and Jin-Haeng Chung, MD, PhD* EGFR mutations were more frequently observed in tumors with BAC Introduction: Epidermal growth factor receptor (EGFR) mutation or papillary components than those with mucinous BAC or solid has been known to be associated with adenocarcinoma with bron- components. Identical EGFR mutations were detected in a single tumor chioloalveolar carcinoma (BAC; lepidic) feature. This study was showing mixed histological features. EGFR protein expression was aimed to characterize the frequency of EGFR mutations and their seen more frequently in tumors with EGFR mutations than those without association with histologic subtypes in Korean nonsmall cell lung EGFR mutations (75.3% versus 24.7%, p 0.003). EGFR mutations were cancer (NSCLC) patients. significantly more common in tumors with thyroid transcription factor-1 Methods: Three hundred eighty-two (88 biopsies and 294 resec- (TTF-1) expression than those without TTF-1 (p  0.001), and almost

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Feb 1, 2012

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