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High-risk human papillomavirus genotypes distribution in a cohort of HIV-positive women living in Europe: epidemiological implication for vaccination against human papillomavirus

High-risk human papillomavirus genotypes distribution in a cohort of HIV-positive women living in... Downloaded from http://journals.lww.com/aidsonline by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/03/2020 High-risk human papillomavirus genotypes distribution in a cohort of HIV-positive women living in Europe: epidemiological implication for vaccination against human papillomavirus a b b Deborah Konopnicki , Yannick Manigart , Christine Gilles , b c d Patricia Barlow ,Je ´ rome De Marchin , Francesco Feoli , a a a Marc Delforge , Nathan Clumeck and Ste ´ phane De Wit Background: Worldwide, human papillomavirus (HPV) 16 and 18 represents 70% of high-risk (HR) HPV found in cervical cancer. However HIV-positive women are more frequently infected by HRHPV other than HPV 16 or 18 (OHR). We aimed to analyse the HRHPV genotype distribution in a cohort of HIV-positive women and to estimate the potential protection offered by the different HPV vaccines. Methods: HRHPV genotypes by PCR and cytology were assessed in cervical samples from 508 HIV-positive women prospectively followed in Brussels. Results: Women characteristics were as follows: African origin (84%), median age 42 years, median CD4 T 555/ml, 89% under combined antiretroviral therapy and 73% with HIVRNA less than 20 copies/ml. HRHPV prevalence was 23% (116/508): 38% had abnormal cytology, 76% carried OHR without HPV 16 or 18 and 11% had concomitant http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AIDS Wolters Kluwer Health

High-risk human papillomavirus genotypes distribution in a cohort of HIV-positive women living in Europe: epidemiological implication for vaccination against human papillomavirus

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References (31)

Publisher
Wolters Kluwer Health
ISSN
0269-9370
eISSN
1473-5571
DOI
10.1097/QAD.0000000000000929
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://journals.lww.com/aidsonline by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/03/2020 High-risk human papillomavirus genotypes distribution in a cohort of HIV-positive women living in Europe: epidemiological implication for vaccination against human papillomavirus a b b Deborah Konopnicki , Yannick Manigart , Christine Gilles , b c d Patricia Barlow ,Je ´ rome De Marchin , Francesco Feoli , a a a Marc Delforge , Nathan Clumeck and Ste ´ phane De Wit Background: Worldwide, human papillomavirus (HPV) 16 and 18 represents 70% of high-risk (HR) HPV found in cervical cancer. However HIV-positive women are more frequently infected by HRHPV other than HPV 16 or 18 (OHR). We aimed to analyse the HRHPV genotype distribution in a cohort of HIV-positive women and to estimate the potential protection offered by the different HPV vaccines. Methods: HRHPV genotypes by PCR and cytology were assessed in cervical samples from 508 HIV-positive women prospectively followed in Brussels. Results: Women characteristics were as follows: African origin (84%), median age 42 years, median CD4 T 555/ml, 89% under combined antiretroviral therapy and 73% with HIVRNA less than 20 copies/ml. HRHPV prevalence was 23% (116/508): 38% had abnormal cytology, 76% carried OHR without HPV 16 or 18 and 11% had concomitant

Journal

AIDSWolters Kluwer Health

Published: Jan 1, 2016

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