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ORIGINAL ARTICLE Increased Lung Cancer Risk among Patients with Pulmonary Tuberculosis A Population Cohort Study Yang-Hao Yu, MD,* Chien-Chang Liao, PhD, MS,†‡ Wu-Huei Hsu, MD,* Hung-Jen Chen, MD,* Wei-Chih Liao, MD,* Chih-Hsin Muo, MS,†‡ Fung-Chang Sung, PhD, MPH,†‡ and Chih-Yi Chen, MD§ Key Words: Lung cancer, Tuberculosis, Chronic obstructive pul- Introduction: Given one third of the human population have been monary disease, Comorbidity, Retrospective cohort study. infected with tuberculosis, it is important to delineate the relation- ship between tuberculosis and lung cancer. This study explored (J Thorac Oncol. 2011;6: 32–37) whether contracting pulmonary tuberculosis is associated with an increased risk of developing lung cancers. ung cancers are among the neoplastic diseases with the Methods: In a cohort of 716,872 insured subjects, free from cancers, Lworst prognosis. The etiology of the disease has been aged 20 years and older, 4480 patients with newly diagnosed associated with smoking, occupational exposure to arsenates, tuberculosis were identiﬁed from the universal insurance claims in nitrosamines, asbestos, and aromatics, and indoor exposures 1998 –2000 and tracked until 2007 with the remaining insured 1– 4 to radon, and to fumes from ﬁres or cooking stoves. without tuberculosis. We compared the incidence of lung cancers Outdoor air
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jan 1, 2011
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