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Influence of Preoperative Radiation Field on Postoperative Leak Rates in Esophageal Cancer Patients after Trimodality Therapy

Influence of Preoperative Radiation Field on Postoperative Leak Rates in Esophageal Cancer... ORIGINAL ARTICLE Influence of Preoperative Radiation Field on Postoperative  Leak Rates in Esophageal Cancer Patients  after Trimodality Therapy Aditya Juloori, BS,* Susan L. Tucker, PhD,† Ritsuko Komaki, MD,* Zhongxing Liao, MD,* Arlene M. Correa, PhD,‡ Stephen G. Swisher, MD,‡ Wayne L. Hofstetter, MD,‡ and Steven H. Lin, MD, PhD*‡ among other factors. Surgical planning should include a critical eval- Introduction: Postoperative morbidities, such as anastomotic leaks, uation of the preoperative radiation fields to ensure proper anasto- are common after trimodality therapy (chemoradiation followed by motic placement after chemoradiation therapy. surgery) for esophageal cancer. We investigated for factors associ- ated with an increased incidence of anastomotic leaks. Key Words: Anastomotic leaks, Esophagectomy, Radiation, Methods: Data from 285 esophageal cancer patients treated from Esophageal cancer, Trimodality therapy. 2000 to 2011 with trimodality therapy were analyzed. Anastomotic (J Thorac Oncol. 2014;9: 534–540) location relative to preoperative radiation field was assessed using postoperative computed tomographic imaging. Logistic regression was used to evaluate for factors associated with any or clinically rel- urgical resection alone remains a worldwide standard for evant (CR) (≥ grade 2) leaks. Sthe management of esophageal cancer, but the 5-year sur- Results: Overall anastomotic leak rate was 11% (31 of 285), and CR vival usually does not exceed 20%. Neoadjuvant chemora- leak rate was http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Influence of Preoperative Radiation Field on Postoperative Leak Rates in Esophageal Cancer Patients after Trimodality Therapy

Journal of Thoracic Oncology , Volume 9 (4) – Apr 1, 2014

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Copyright
Copyright © 2014 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
DOI
10.1097/JTO.0000000000000100
pmid
24736077
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Influence of Preoperative Radiation Field on Postoperative  Leak Rates in Esophageal Cancer Patients  after Trimodality Therapy Aditya Juloori, BS,* Susan L. Tucker, PhD,† Ritsuko Komaki, MD,* Zhongxing Liao, MD,* Arlene M. Correa, PhD,‡ Stephen G. Swisher, MD,‡ Wayne L. Hofstetter, MD,‡ and Steven H. Lin, MD, PhD*‡ among other factors. Surgical planning should include a critical eval- Introduction: Postoperative morbidities, such as anastomotic leaks, uation of the preoperative radiation fields to ensure proper anasto- are common after trimodality therapy (chemoradiation followed by motic placement after chemoradiation therapy. surgery) for esophageal cancer. We investigated for factors associ- ated with an increased incidence of anastomotic leaks. Key Words: Anastomotic leaks, Esophagectomy, Radiation, Methods: Data from 285 esophageal cancer patients treated from Esophageal cancer, Trimodality therapy. 2000 to 2011 with trimodality therapy were analyzed. Anastomotic (J Thorac Oncol. 2014;9: 534–540) location relative to preoperative radiation field was assessed using postoperative computed tomographic imaging. Logistic regression was used to evaluate for factors associated with any or clinically rel- urgical resection alone remains a worldwide standard for evant (CR) (≥ grade 2) leaks. Sthe management of esophageal cancer, but the 5-year sur- Results: Overall anastomotic leak rate was 11% (31 of 285), and CR vival usually does not exceed 20%. Neoadjuvant chemora- leak rate was

Journal

Journal of Thoracic OncologyWolters Kluwer Health

Published: Apr 1, 2014

References