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Liver fibrosis in HIV which role does HIV itself, long-term drug toxicities and metabolic changes play?

Liver fibrosis in HIV which role does HIV itself, long-term drug toxicities and metabolic... REVIEW URRENT Liver fibrosis in HIV: which role does HIV itself, PINION long-term drug toxicities and metabolic changes play? a,b a,b c,d Ju¨rgen K. Rockstroh , Raphael Mohr , Georg Behrens , and a,b Ulrich Spengler Purpose of review Liver disease is one of the main causes of non-AIDS death in HIV-infected individuals from Europe and North America and has been attributed mainly to coinfection with hepatotropic viruses. However, HIV- induced inflammation as well as long-term antiretroviral drug toxicity may also contribute to clinical relevant liver disease. Therefore, a better understanding of liver disease beyond viral hepatitis coinfection is urgently needed in HIV-infected individuals. Recent findings Cross-sectional fibroscan studies in HIV-infected patient populations have reported unexpectedly high rates of advance fibrosis in HIV-infected patients even without underlying viral hepatitis or alcohol abuse suggesting that HIV itself may contribute independently to liver disease. Finally, HIV therapy itself either through direct hepatotoxicity or long-term metabolic changes, such as dyslipidemia and/or insulin resistance, may additionally cause liver damage in life long treatment. Summary Therefore, aging of the liver in HIV may play a much more pivotal role in the future considering age-related effects, coinfection with hepatotropic viruses and the toxicity of long-term http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Liver fibrosis in HIV which role does HIV itself, long-term drug toxicities and metabolic changes play?

Spengler, Ulrich
Current Opinion in HIV and Aids , Volume 9 (4) – Jul 1, 2014
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© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1746-630X
eISSN
1746-6318

Abstract

REVIEW URRENT Liver fibrosis in HIV: which role does HIV itself, PINION long-term drug toxicities and metabolic changes play? a,b a,b c,d Ju¨rgen K. Rockstroh , Raphael Mohr , Georg Behrens , and a,b Ulrich Spengler Purpose of review Liver disease is one of the main causes of non-AIDS death in HIV-infected individuals from Europe and North America and has been attributed mainly to coinfection with hepatotropic viruses. However, HIV- induced inflammation as well as long-term antiretroviral drug toxicity may also contribute to clinical relevant liver disease. Therefore, a better understanding of liver disease beyond viral hepatitis coinfection is urgently needed in HIV-infected individuals. Recent findings Cross-sectional fibroscan studies in HIV-infected patient populations have reported unexpectedly high rates of advance fibrosis in HIV-infected patients even without underlying viral hepatitis or alcohol abuse suggesting that HIV itself may contribute independently to liver disease. Finally, HIV therapy itself either through direct hepatotoxicity or long-term metabolic changes, such as dyslipidemia and/or insulin resistance, may additionally cause liver damage in life long treatment. Summary Therefore, aging of the liver in HIV may play a much more pivotal role in the future considering age-related effects, coinfection with hepatotropic viruses and the toxicity of long-term

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Jul 1, 2014

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