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Low rates of acceptance of BRCA1 BRCA2

Low rates of acceptance of BRCA1 BRCA2 article September 2006  Vol. 8  No. 9 Low rates of acceptance of BRCA1 and BRCA2 test results among African American women at increased risk for hereditary breast-ovarian cancer 1 2 3 4 2 Chanita Hughes Halbert, PhD , Lisa Kessler, MS , Jill E. Stopfer, MS , Susan Domchek, MD , and E. Paul Wileyto, PhD Purpose: This study evaluated rates of BRCA1 and BRCA2 (BRCA1/2) test result acceptance among African American women and identified determinants of test result acceptance. Methods: Acceptance of BRCA1/2 test results was evaluated among 157 African American women at high and moderate risk for having a BRCA1/2 mutation who were offered genetic testing as part of a clinical genetic counseling research program. Results: Twenty-two percent of women received BRCA1/2 test results. Test result acceptance differed between women with 10% prior probability of having a BRCA1/2 mutation (34%) and those who had a 5% prior probability (8%). Among women with 10% prior probability, test result acceptors were most likely to be married (OR  5.29, 95% CI 1.82, 15.38, P  0.002) and be less certain about their risk of developing cancer (OR  3.18, 95% CI  1.04, 9.80, P  0.04). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetics in Medicine Wolters Kluwer Health

Low rates of acceptance of BRCA1 BRCA2

Genetics in Medicine , Volume 8 (9) – Sep 1, 2006

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References (43)

ISSN
1098-3600
DOI
10.1097/01.gim.0000237719.37908.54
Publisher site
See Article on Publisher Site

Abstract

article September 2006  Vol. 8  No. 9 Low rates of acceptance of BRCA1 and BRCA2 test results among African American women at increased risk for hereditary breast-ovarian cancer 1 2 3 4 2 Chanita Hughes Halbert, PhD , Lisa Kessler, MS , Jill E. Stopfer, MS , Susan Domchek, MD , and E. Paul Wileyto, PhD Purpose: This study evaluated rates of BRCA1 and BRCA2 (BRCA1/2) test result acceptance among African American women and identified determinants of test result acceptance. Methods: Acceptance of BRCA1/2 test results was evaluated among 157 African American women at high and moderate risk for having a BRCA1/2 mutation who were offered genetic testing as part of a clinical genetic counseling research program. Results: Twenty-two percent of women received BRCA1/2 test results. Test result acceptance differed between women with 10% prior probability of having a BRCA1/2 mutation (34%) and those who had a 5% prior probability (8%). Among women with 10% prior probability, test result acceptors were most likely to be married (OR  5.29, 95% CI 1.82, 15.38, P  0.002) and be less certain about their risk of developing cancer (OR  3.18, 95% CI  1.04, 9.80, P  0.04).

Journal

Genetics in MedicineWolters Kluwer Health

Published: Sep 1, 2006

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