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Lymph Nodes Involved by Multicentric Castleman Disease Among HIV-positive Individuals are Often Involved by Kaposi Sarcoma

Lymph Nodes Involved by Multicentric Castleman Disease Among HIV-positive Individuals are Often... ORIGINAL ARTICLE Lymph Nodes Involved by Multicentric Castleman Disease Among HIV-positive Individuals are Often Involved by Kaposi Sarcoma Kikkeri N. Naresh, MD, MRCPath,* Alexandra J. Rice, MRCPath,w and Mark Bower, PhD, FRCP, FRCPathz CD is a rare lymphoproliferative disorder occurring Abstract: Multicentric Castleman disease (MCD), a lympho- Mmore frequently in patients infected with human proliferative disorder and Kaposi sarcoma (KS), a vascular immunodeficiency virus (HIV), who present with con- tumor, both occur at a higher frequency among patients with stitutional symptoms, generalized lymphadenopathy, human immunodeficiency virus (HIV) infection. Human herpes hepatosplenomegaly, polyclonal hypergammaglobuline- virus 8 (HHV8), with an ability to infect and persist in mia, and elevated levels of serum interleukin-6 (IL-6). On B-lymphoid cells and endothelial cells, is causally associated with histologic evaluation, the lymph nodes (LNs) show both MCD and KS. The coexistence of these HHV8-associated follicles with relative paucity of germinal center cells diseases in the same tissue samples has hitherto not been and some degree of hyalinization, and expansion of investigated. In this report, we compile the histologic and mantle zones. Interfollicular areas are rich in plasma cells. immunohistochemical findings in 24 lymph node (LN) and 5 In addition, the mantle zone contains variable number http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Surgical Pathology Wolters Kluwer Health

Lymph Nodes Involved by Multicentric Castleman Disease Among HIV-positive Individuals are Often Involved by Kaposi Sarcoma

American Journal of Surgical Pathology , Volume 32 (7) – Jul 1, 2008

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References (26)

ISSN
0147-5185
eISSN
1532-0979
DOI
10.1097/PAS.0b013e318160ed97
pmid
18469709
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Lymph Nodes Involved by Multicentric Castleman Disease Among HIV-positive Individuals are Often Involved by Kaposi Sarcoma Kikkeri N. Naresh, MD, MRCPath,* Alexandra J. Rice, MRCPath,w and Mark Bower, PhD, FRCP, FRCPathz CD is a rare lymphoproliferative disorder occurring Abstract: Multicentric Castleman disease (MCD), a lympho- Mmore frequently in patients infected with human proliferative disorder and Kaposi sarcoma (KS), a vascular immunodeficiency virus (HIV), who present with con- tumor, both occur at a higher frequency among patients with stitutional symptoms, generalized lymphadenopathy, human immunodeficiency virus (HIV) infection. Human herpes hepatosplenomegaly, polyclonal hypergammaglobuline- virus 8 (HHV8), with an ability to infect and persist in mia, and elevated levels of serum interleukin-6 (IL-6). On B-lymphoid cells and endothelial cells, is causally associated with histologic evaluation, the lymph nodes (LNs) show both MCD and KS. The coexistence of these HHV8-associated follicles with relative paucity of germinal center cells diseases in the same tissue samples has hitherto not been and some degree of hyalinization, and expansion of investigated. In this report, we compile the histologic and mantle zones. Interfollicular areas are rich in plasma cells. immunohistochemical findings in 24 lymph node (LN) and 5 In addition, the mantle zone contains variable number

Journal

American Journal of Surgical PathologyWolters Kluwer Health

Published: Jul 1, 2008

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