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Management of Mediastinal Relapse after Treatment with Stereotactic Body Radiotherapy or Accelerated Hypofractionated Radiotherapy for Stage I/II Non–Small-Cell Lung Cancer

Management of Mediastinal Relapse after Treatment with Stereotactic Body Radiotherapy or... BRIEF REPORT Management of Mediastinal Relapse after Treatment  with Stereotactic Body Radiotherapy or Accelerated  Hypofractionated Radiotherapy for Stage I/II  Non–Small-Cell Lung Cancer Jeremy M. Kilburn, MD,* Scott C. Lester, BS,* John T. Lucas Jr, MS, MD,* Michael H. Soike, BS,* A. William Blackstock, MD,* William T. Kearns, MS,* William H. Hinson, PhD,* Antonius A. Miller, MD,† William J. Petty, MD,† Michael T. Munley, PhD,* and James J. Urbanic, MD* egional relapse after stereotactic body radiotherapy Purpose/Objective(s): Regional failures occur in up to 15% of R(SBRT) in early-stage lung cancer is seen in up to 10% patients treated with stereotactic body radiotherapy (SBRT) for stage to 15% of patients. Inoperable patients with metastases to I/II lung cancer. This report focuses on the management of the unique regional lymph nodes (American Joint Committee on Cancer scenario of isolated regional failures. Staging 7th edition, N1 or N2) at presentation are treated with Methods: Patients treated initially with SBRT or accelerated hypo- chemoradiotherapy, and it therefore stands to reason patients fractionated radiotherapy were screened for curative intent treatment with regional failures would benefit from a similar treatment. of isolated mediastinal failures (IMFs). Local control, regional con- Despite this logical argument, the successful salvage trol, progression-free survival, and distant control were estimated rate after external beam radiotherapy (EBRT) with or http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Management of Mediastinal Relapse after Treatment with Stereotactic Body Radiotherapy or Accelerated Hypofractionated Radiotherapy for Stage I/II Non–Small-Cell Lung Cancer

Urbanic, James J.
Journal of Thoracic Oncology , Volume 9 (4) – Apr 1, 2014
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Copyright
Copyright © 2014 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
eISSN
1556-1380
DOI
10.1097/JTO.0000000000000086
pmid
24736084
Publisher site
See Article on Publisher Site

Abstract

BRIEF REPORT Management of Mediastinal Relapse after Treatment  with Stereotactic Body Radiotherapy or Accelerated  Hypofractionated Radiotherapy for Stage I/II  Non–Small-Cell Lung Cancer Jeremy M. Kilburn, MD,* Scott C. Lester, BS,* John T. Lucas Jr, MS, MD,* Michael H. Soike, BS,* A. William Blackstock, MD,* William T. Kearns, MS,* William H. Hinson, PhD,* Antonius A. Miller, MD,† William J. Petty, MD,† Michael T. Munley, PhD,* and James J. Urbanic, MD* egional relapse after stereotactic body radiotherapy Purpose/Objective(s): Regional failures occur in up to 15% of R(SBRT) in early-stage lung cancer is seen in up to 10% patients treated with stereotactic body radiotherapy (SBRT) for stage to 15% of patients. Inoperable patients with metastases to I/II lung cancer. This report focuses on the management of the unique regional lymph nodes (American Joint Committee on Cancer scenario of isolated regional failures. Staging 7th edition, N1 or N2) at presentation are treated with Methods: Patients treated initially with SBRT or accelerated hypo- chemoradiotherapy, and it therefore stands to reason patients fractionated radiotherapy were screened for curative intent treatment with regional failures would benefit from a similar treatment. of isolated mediastinal failures (IMFs). Local control, regional con- Despite this logical argument, the successful salvage trol, progression-free survival, and distant control were estimated rate after external beam radiotherapy (EBRT) with or

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Apr 1, 2014

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