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Mutations and Protein Expression of KIT PDGFRA An Immunohistochemical and Molecular Genetic Study

Mutations and Protein Expression of KIT PDGFRA An Immunohistochemical and Molecular Genetic Study RESEARCH ARTICLE Mutations and Protein Expression of KIT and PDGFRA Genes in Ipsilateral Testicular Seminomas: An Immunohistochemical and Molecular Genetic Study Tadashi Terada, MD, PhD 6–9 and tumorigenesis. Previous studies have shown that Abstract: Protein expression and gene mutational status of KIT activating mutation of KIT gene may lead to germ cell 6–9 and PDGFRA were investigated in formalin-fixed, paraffin- tumors including seminomas. One study has shown that embedded specimens of 14 ipsilateral testicular seminomas. The PDGFRA transcripts are present in early stages of germ cell analysis was performed by ordinary immunohistochemistry and tumorigenesis. However, PDGFRA gene mutations in polymerase chain reaction-direct sequencing methods. The genetic clinical seminomas have not been estimated. In the present analysis was performed in exons 9, 11, 13, and 17 of KIT gene and study, the author investigated the gene mutations and in exons 12 and 18 of PDGFRA gene. Six point mutations of 5 protein expression of KIT and PDGFRA in 14 pure classic types of KIT gene were recognized in 5 (36%) cases; exon 17 ipsilateral seminomas. around codon 816 was a hotspot. The mutation sites of KIT gene were as follows: codon 557 in exon 11 (1 case), codon 816 in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Mutations and Protein Expression of KIT PDGFRA An Immunohistochemical and Molecular Genetic Study

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References (15)

Copyright
Copyright © 2011 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e31820d2872
pmid
21403518
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Mutations and Protein Expression of KIT and PDGFRA Genes in Ipsilateral Testicular Seminomas: An Immunohistochemical and Molecular Genetic Study Tadashi Terada, MD, PhD 6–9 and tumorigenesis. Previous studies have shown that Abstract: Protein expression and gene mutational status of KIT activating mutation of KIT gene may lead to germ cell 6–9 and PDGFRA were investigated in formalin-fixed, paraffin- tumors including seminomas. One study has shown that embedded specimens of 14 ipsilateral testicular seminomas. The PDGFRA transcripts are present in early stages of germ cell analysis was performed by ordinary immunohistochemistry and tumorigenesis. However, PDGFRA gene mutations in polymerase chain reaction-direct sequencing methods. The genetic clinical seminomas have not been estimated. In the present analysis was performed in exons 9, 11, 13, and 17 of KIT gene and study, the author investigated the gene mutations and in exons 12 and 18 of PDGFRA gene. Six point mutations of 5 protein expression of KIT and PDGFRA in 14 pure classic types of KIT gene were recognized in 5 (36%) cases; exon 17 ipsilateral seminomas. around codon 816 was a hotspot. The mutation sites of KIT gene were as follows: codon 557 in exon 11 (1 case), codon 816 in

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Oct 1, 2011

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