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EDITORIAL National Lung Cancer Screening Trial American College of Radiology Imaging Network Specimen Biorepository Originating from the Contemporary Screening for the Detection of Lung Cancer Trial (NLST, ACRIN 6654) Design, Intent, and Availability of Specimens for Validation of Lung Cancer Biomarkers Edward F. Patz, Jr., MD,*† Neil E. Caporaso, PhD,‡ Steven M. Dubinett, MD,§ Pierre P. Massion, MD, Fred R. Hirsch, MD, PhD,¶ John D. Minna, MD,# Constantine Gatsonis, PhD,** Fenghai Duan, PhD,** Amanda Adams, MPH,** Charles Apgar, MBA,†† Rosa M. Medina, BS,†† and Denise R. Aberle, MD‡‡ he National Lung Cancer Screening Trial (NLST) is a cooperative, National Cancer TInstitute (NCI)-sponsored randomized trial that was initiated in 2002 with the primary goal to determine whether screening for lung cancer with computed tomography (CT), when compared with chest radiographs, reduces lung cancer specific mortality. The trial represented a merger of two NCI-sponsored activities, the NCI Lung Screening Study and the American College of Radiology Imaging Network (ACRIN). It enrolled more than 50,000 high-risk individuals (heavy current cigarette smokers or former smokers) from more than 30 sites across the United States. The ACRIN arm (ACRIN 6654) accrued 18,842 participants. These participants, aged 55 to 74 years, will be followed up
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Oct 1, 2010
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