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Original Atricle Neutrophil–Lymphocyte and Platelet–Lymphocyte Ratios as Prognostic Factors after Stereotactic Radiation Therapy for Early-Stage Non–Small-Cell Lung Cancer Nathan A. Cannon, MD, PhD,* Jeffrey Meyer, MD,* Puneeth Iyengar, MD, PhD,* Chul Ahn, PhD,† Kenneth D. Westover, MD, PhD,* Hak Choy, MD,* and Robert Timmerman, MD* those patients where lobectomy is not an option, such as for Introduction: The hematologic indices of neutrophil-to-lymphocyte medically inoperable patients or for those unwilling to undergo ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are correlated surgery, stereotactic body radiation therapy, also known as with clinical outcomes after stereotactic radiation. stereotactic ablative radiotherapy (SABR), has shown efficacy Methods: We retrospectively evaluated the pretreatment NLR and with improved local control and survival outcomes relative to PLR in patients treated with stereotactic radiation for early stage traditional radiation therapy. non–small-cell lung cancer at our institution. A total of 149 patients The cellular components of the host hematologic sys- treated for non–small-cell lung cancer were identified, and 59 had tem, including cells involved in hemostasis, inflammation, and stage I disease with neutrophil, platelet, and lymphocyte levels within immunity, may influence survival outcomes in patients with a 3-month period before treatment. Receiver operating characteristic cancer. The neutrophil-to-lymphocyte ratio (NLR) is an easily (ROC) analysis was performed to examine cutoff values for survival derived
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Feb 1, 2015
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