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Ovarian Conservation at the Time of Hysterectomy and Long-Term Health Outcomes in the Nurses’ Health Study

Ovarian Conservation at the Time of Hysterectomy and Long-Term Health Outcomes in the... Ovarian Conservation at the Time of Hysterectomy and Long-Term Health Outcomes in the Nurses’ Health Study William H. Parker, MD, Michael S. Broder, MD, MPH, Eunice Chang, PhD, Diane Feskanich, ScD, Cindy Farquhar, MD, Zhimae Liu, PhD, Donna Shoupe, MD, Jonathan S. Berek, MD, MMS, Susan Hankinson, ScD, and JoAnn E. Manson, MD, DrPH OBJECTIVE: To report long-term health outcomes and ovarian cancer, lung cancer, colorectal cancer, total can- mortality after oophorectomy or ovarian conservation. cers, hip fracture, pulmonary embolus, and death from all causes. METHODS: We conducted a prospective, observational RESULTS: Over 24 years of follow-up, for women with study of 29,380 women participants of the Nurses’ Health hysterectomy and bilateral oophorectomy compared Study who had a hysterectomy for benign disease; 16,345 with ovarian conservation, the multivariable hazard ratios (55.6%) had hysterectomy with bilateral oophorectomy, (HRs) were 1.12 (95% confidence interval [CI] 1.03–1.21) and 13,035 (44.4%) had hysterectomy with ovarian con- for total mortality, 1.17 (95% CI 1.02–1.35) for fatal plus servation. We evaluated incident events or death due to nonfatal CHD, and 1.14 (95% CI 0.98–1.33) for stroke. coronary heart disease (CHD), stroke, breast cancer, Although the risks of breast (HR 0.75, 95% CI 0.68–0.84), ovarian (HR http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Obstetrics & Gynecology Wolters Kluwer Health

Ovarian Conservation at the Time of Hysterectomy and Long-Term Health Outcomes in the Nurses’ Health Study

Obstetrics & Gynecology , Volume 113 (5) – May 1, 2009

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References (30)

ISSN
0029-7844
eISSN
1873-233X
DOI
10.1097/AOG.0b013e3181a11c64
pmid
19384117
Publisher site
See Article on Publisher Site

Abstract

Ovarian Conservation at the Time of Hysterectomy and Long-Term Health Outcomes in the Nurses’ Health Study William H. Parker, MD, Michael S. Broder, MD, MPH, Eunice Chang, PhD, Diane Feskanich, ScD, Cindy Farquhar, MD, Zhimae Liu, PhD, Donna Shoupe, MD, Jonathan S. Berek, MD, MMS, Susan Hankinson, ScD, and JoAnn E. Manson, MD, DrPH OBJECTIVE: To report long-term health outcomes and ovarian cancer, lung cancer, colorectal cancer, total can- mortality after oophorectomy or ovarian conservation. cers, hip fracture, pulmonary embolus, and death from all causes. METHODS: We conducted a prospective, observational RESULTS: Over 24 years of follow-up, for women with study of 29,380 women participants of the Nurses’ Health hysterectomy and bilateral oophorectomy compared Study who had a hysterectomy for benign disease; 16,345 with ovarian conservation, the multivariable hazard ratios (55.6%) had hysterectomy with bilateral oophorectomy, (HRs) were 1.12 (95% confidence interval [CI] 1.03–1.21) and 13,035 (44.4%) had hysterectomy with ovarian con- for total mortality, 1.17 (95% CI 1.02–1.35) for fatal plus servation. We evaluated incident events or death due to nonfatal CHD, and 1.14 (95% CI 0.98–1.33) for stroke. coronary heart disease (CHD), stroke, breast cancer, Although the risks of breast (HR 0.75, 95% CI 0.68–0.84), ovarian (HR

Journal

Obstetrics & GynecologyWolters Kluwer Health

Published: May 1, 2009

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