Get 20M+ Full-Text Papers For Less Than $1.50/day. Subscribe now for You or Your Team.

Learn More →

Pancreatic Secretory Trypsin Inhibitor SPINK1

Pancreatic Secretory Trypsin Inhibitor SPINK1 ORIGINAL ARTICLE Pancreatic Secretory Trypsin Inhibitor (SPINK1) Gene Mutations in Patients With Acute Pancreatitis Eija Tukiainen, MD,* Marja-Leena Kyla ¨ npa ¨a ¨ , MD, PhD,* Esko Kemppainen, MD, PhD,* Heli Nevanlinna, PhD,† Annukka Paju, PhD,‡ Heikki Repo, MD, PhD,§ Ulf-Ha ˚ kan Stenman, MD, PhD,‡ and Pauli Puolakkainen, MD, PhD* INTRODUCTION Objectives: Mutations in the secretory trypsin inhibitor (SPINK1) Acute pancreatitis (AP) is a common presentation at an gene have been found to be associated with hereditary and chronic emergency unit. The incidence of the disease is growing and pancreatitis. There are no previous reports on SPINK1 mutations in 1 varies from one country to another. The most common etio- patients with acute pancreatitis (AP). logic factors of AP are alcohol abuse and gallstone disease. Less common causes include anatomic abnormalities, hyper- Methods: The study population consists of 371 patients with AP, of triglyceridemia, and drugs, whereas some cases are idiopathic. which 207 patients had mild and 164 had a severe form of the disease. Gallstone disease is the leading etiologic factor in most The etiologies of AP were identified. Four hundred fifty-nine blood developed countries, but in Finland, alcohol is the most donors served as controls. SPINK1 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pancreas Wolters Kluwer Health

Pancreatic Secretory Trypsin Inhibitor SPINK1

Pancreas , Volume 30 (3) – Apr 1, 2005

Loading next page...
 
/lp/wolters-kluwer-health/pancreatic-secretory-trypsin-inhibitor-spink1-Cbr5R2Wb6Z

References (27)

Copyright
Copyright © 2005 by Lippincott Williams & Wilkins
ISSN
0885-3177
eISSN
1536-4828
DOI
10.1097/01.mpa.0000157479.84036.ed
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Pancreatic Secretory Trypsin Inhibitor (SPINK1) Gene Mutations in Patients With Acute Pancreatitis Eija Tukiainen, MD,* Marja-Leena Kyla ¨ npa ¨a ¨ , MD, PhD,* Esko Kemppainen, MD, PhD,* Heli Nevanlinna, PhD,† Annukka Paju, PhD,‡ Heikki Repo, MD, PhD,§ Ulf-Ha ˚ kan Stenman, MD, PhD,‡ and Pauli Puolakkainen, MD, PhD* INTRODUCTION Objectives: Mutations in the secretory trypsin inhibitor (SPINK1) Acute pancreatitis (AP) is a common presentation at an gene have been found to be associated with hereditary and chronic emergency unit. The incidence of the disease is growing and pancreatitis. There are no previous reports on SPINK1 mutations in 1 varies from one country to another. The most common etio- patients with acute pancreatitis (AP). logic factors of AP are alcohol abuse and gallstone disease. Less common causes include anatomic abnormalities, hyper- Methods: The study population consists of 371 patients with AP, of triglyceridemia, and drugs, whereas some cases are idiopathic. which 207 patients had mild and 164 had a severe form of the disease. Gallstone disease is the leading etiologic factor in most The etiologies of AP were identified. Four hundred fifty-nine blood developed countries, but in Finland, alcohol is the most donors served as controls. SPINK1

Journal

PancreasWolters Kluwer Health

Published: Apr 1, 2005

There are no references for this article.