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Perspectives on interleukin-7 therapy in HIV infection

Perspectives on interleukin-7 therapy in HIV infection Jean Daniel Lelie ` vre and Yves Le ´ vy Purpose of review Introduction HIV infection is characterized by depletion of CD4 T cells The immune system, similar to other biological systems, and altered immune function, leading to severe immune is subject to homeostatic regulation, which ensures that deficiency. Mechanisms leading to this T-cell depletion are there is a largely constant total number of lymphocytes in not completely understood. Potent antiretroviral therapy the periphery. Maintenance of this equilibrium is restores T-cell counts and improves prognosis. Apart from achieved through complex cellular interactions that antiviral therapy for the infection, immunotherapies such as control cell proliferation, differentiation and death, and interleukin-7 that influence T-cell homeostatic mechanisms through numerous cytokines and interactions with the are undergoing clinical evaluation. Because of its environment (i.e. bone marrow, thymus, spleen, intestine pleiotropic effects on developing and mature T cells, and lymph nodes) in which the early and final processes interleukin-7 may help to restore immune function during in T-cell differentiation take place. Re-establishment of HIV infection. the status quo is possible in a relatively unperturbed Recent findings immune system, but immune function is compromised Recent studies explored the therapeutic use of interleukin-7 in situations involving http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Perspectives on interleukin-7 therapy in HIV infection

Lé vy, Yves
Current Opinion in HIV and Aids , Volume 2 (3) – May 1, 2007
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ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e3280fb27a5
pmid
19372891
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Abstract

Jean Daniel Lelie ` vre and Yves Le ´ vy Purpose of review Introduction HIV infection is characterized by depletion of CD4 T cells The immune system, similar to other biological systems, and altered immune function, leading to severe immune is subject to homeostatic regulation, which ensures that deficiency. Mechanisms leading to this T-cell depletion are there is a largely constant total number of lymphocytes in not completely understood. Potent antiretroviral therapy the periphery. Maintenance of this equilibrium is restores T-cell counts and improves prognosis. Apart from achieved through complex cellular interactions that antiviral therapy for the infection, immunotherapies such as control cell proliferation, differentiation and death, and interleukin-7 that influence T-cell homeostatic mechanisms through numerous cytokines and interactions with the are undergoing clinical evaluation. Because of its environment (i.e. bone marrow, thymus, spleen, intestine pleiotropic effects on developing and mature T cells, and lymph nodes) in which the early and final processes interleukin-7 may help to restore immune function during in T-cell differentiation take place. Re-establishment of HIV infection. the status quo is possible in a relatively unperturbed Recent findings immune system, but immune function is compromised Recent studies explored the therapeutic use of interleukin-7 in situations involving

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: May 1, 2007

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