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Positive association of neuroligin-4 gene with nonspecific mental retardation in the Qinba Mountains Region of China

Positive association of neuroligin-4 gene with nonspecific mental retardation in the Qinba... Original article 1 Positive association of neuroligin-4 gene with nonspecific mental retardation in the Qinba Mountains Region of China a,b b a,b a,b,c a,b,c Hongbin Qi , Lianxi Xing , Kejin Zhang , Xiaocai Gao , Zijian Zheng , d d a,b,c Shaoping Huang , Yale Guo and Fuchang Zhang Objective Neuroligin-4 is essential for proper brain df = 2, global P = 0.034; v = 9.29, df = 2, global P = 0.0096, function. Some studies indicate a close relationship respectively). between neuroligin-4 and several human psychiatric conditions. Conclusion The results suggest a positive association between the genetic variants of the NLGN4 and NSMR Methods The case–control method was used to study the in the Chinese children from Qinba Mountains association between nonspecific mental retardation Region. Psychiatr Genet 19:1–5 2009 Wolters Kluwer (NSMR) and genetic variants of neuroligin-4 gene (NLGN4). Health | Lippincott Williams & Wilkins. Five single nucleotide polymorphisms (SNPs: rs5916271, rs7049300, rs6638575, rs3810686, and rs1882260) were Psychiatric Genetics 2009, 19:1–5 genotyped by PCR-RFLP/SSCP method in the NLGN4. Keywords: association study, neuroligin-4 gene, nonspecific mental retardation, single nucleotide polymorphism Results Individual SNP analysis shows significant a b College of Life Science, Institute of Population and Health, Key http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychiatric Genetics Wolters Kluwer Health

Positive association of neuroligin-4 gene with nonspecific mental retardation in the Qinba Mountains Region of China

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ISSN
0955-8829
eISSN
1473-5873
DOI
10.1097/YPG.0b013e3283088e54
pmid
19125102
Publisher site
See Article on Publisher Site

Abstract

Original article 1 Positive association of neuroligin-4 gene with nonspecific mental retardation in the Qinba Mountains Region of China a,b b a,b a,b,c a,b,c Hongbin Qi , Lianxi Xing , Kejin Zhang , Xiaocai Gao , Zijian Zheng , d d a,b,c Shaoping Huang , Yale Guo and Fuchang Zhang Objective Neuroligin-4 is essential for proper brain df = 2, global P = 0.034; v = 9.29, df = 2, global P = 0.0096, function. Some studies indicate a close relationship respectively). between neuroligin-4 and several human psychiatric conditions. Conclusion The results suggest a positive association between the genetic variants of the NLGN4 and NSMR Methods The case–control method was used to study the in the Chinese children from Qinba Mountains association between nonspecific mental retardation Region. Psychiatr Genet 19:1–5 2009 Wolters Kluwer (NSMR) and genetic variants of neuroligin-4 gene (NLGN4). Health | Lippincott Williams & Wilkins. Five single nucleotide polymorphisms (SNPs: rs5916271, rs7049300, rs6638575, rs3810686, and rs1882260) were Psychiatric Genetics 2009, 19:1–5 genotyped by PCR-RFLP/SSCP method in the NLGN4. Keywords: association study, neuroligin-4 gene, nonspecific mental retardation, single nucleotide polymorphism Results Individual SNP analysis shows significant a b College of Life Science, Institute of Population and Health, Key

Journal

Psychiatric GeneticsWolters Kluwer Health

Published: Feb 1, 2009

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