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ORIGINAL ARTICLE Primary Tumor Standardized Uptake Value (SUV ) max Measured on Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) is of Prognostic Value for Survival in Non-small Cell Lung Cancer (NSCLC) A Systematic Review and Meta-Analysis (MA) by the European Lung Cancer Working Party for the IASLC Lung Cancer Staging Project Thierry Berghmans, MD,* Miche `le Dusart, MD,† Marianne Paesmans, MSc,‡ Claude Hossein-Foucher, MD,§ Irene Buvat, PhD, Catherine Castaigne, MD,¶ Arnaud Scherpereel, MD, PhD,# Ce ´line Mascaux, MD,* ** Michel Moreau, MD,‡ Martine Roelandts, MD,†† Ste ´phane Alard, MD,‡‡ Anne-Pascale Meert, MD, PhD,* Edward F. Patz, Jr, MD,§§ Jean-Jacques Lafitte, MD, PhD,# and Jean-Paul Sculier, MD, PhD* significant correlation between SUV and survival. SUV measure- Hypothesis: The 2-[ F]-fluoro-2-deoxy-D-glucose positron emis- ment and SUV threshold for defining high SUV were study depen- sion tomography is an imaging tool for assessing clinical tumor, dent, eight studies looked for a so-called best cutoff (maximizing the node, metastasis in non-small cell lung cancer (NSCLC). Primary logrank test statistic) without adjusting the p value for multiplicity. tumor standardized uptake value (SUV) has been studied as a Overall, the combined HR for the 13 reports was 2.27 (95% potential prognostic factor for survival. However, the sample
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jan 1, 2008
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