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Prognostic Impact of Paraneoplastic Cushing’s Syndrome in Small-Cell Lung Cancer

Prognostic Impact of Paraneoplastic Cushing’s Syndrome in Small-Cell Lung Cancer ORIGINAL ARTICLE Prognostic Impact of Paraneoplastic Cushing’s Syndrome  in Small-Cell Lung Cancer Hélène Nagy-Mignotte, MD,*†‡ Oxana Shestaeva, MD,§ Lucile Vignoud, MSc,† Pascale Guillem, MD,*† Stéphane Ruckly, MSc,† Olivier Chabre, MD, PhD,‖ Linda Sakhri, MD,‡ Michael Duruisseaux, MD,‡ Mireille Mousseau, MD,§ Jean-François Timsit, MD,†¶ and Denis Moro-Sibilot, MD*†‡; for the Multidisciplinary Thoracic Oncology Group at Grenoble University Hospital, France Key Words: Paraneoplastic Cushing’s syndrome, Small-cell lung Introduction: Paraneoplastic Cushing’s syndrome (CushingPS) in cancer, Survival. small-cell lung cancer is rare but severe. Methods: We studied 383 patients with small-cell lung cancer (J Thorac Oncol. 2014;9: 497–505) diagnosed between 1998 and 2012. Among them, 23 patients had CushingPS, 56 had other paraneoplastic syndrome (OtherPS), and 304 had no paraneoplastic syndrome (NoPS). mong lung cancers, the proportion of small-cell lung can- Results: After comparison of the three groups, we observed that 1–5 Acers (SCLC) has decreased over the last 30 years, falling CushingPS patients had more extensive disease: 82.6% versus from 17.26% to 12.95% between 1986 and 2002 in the United 67.8% versus 53.3% (p = 0.005), respectively, with more than two 2 States. In our institution, it has dropped from 22.5% of all lung metastatic sites: 63.2% versus 15.8% and 24.1% (p ≤ 0.001), a higher cancers in 1982 to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Prognostic Impact of Paraneoplastic Cushing’s Syndrome in Small-Cell Lung Cancer

Moro-Sibilot, Denis
Journal of Thoracic Oncology , Volume 9 (4) – Apr 1, 2014
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Copyright
Copyright © 2014 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
DOI
10.1097/JTO.0000000000000116
pmid
24736072
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Prognostic Impact of Paraneoplastic Cushing’s Syndrome  in Small-Cell Lung Cancer Hélène Nagy-Mignotte, MD,*†‡ Oxana Shestaeva, MD,§ Lucile Vignoud, MSc,† Pascale Guillem, MD,*† Stéphane Ruckly, MSc,† Olivier Chabre, MD, PhD,‖ Linda Sakhri, MD,‡ Michael Duruisseaux, MD,‡ Mireille Mousseau, MD,§ Jean-François Timsit, MD,†¶ and Denis Moro-Sibilot, MD*†‡; for the Multidisciplinary Thoracic Oncology Group at Grenoble University Hospital, France Key Words: Paraneoplastic Cushing’s syndrome, Small-cell lung Introduction: Paraneoplastic Cushing’s syndrome (CushingPS) in cancer, Survival. small-cell lung cancer is rare but severe. Methods: We studied 383 patients with small-cell lung cancer (J Thorac Oncol. 2014;9: 497–505) diagnosed between 1998 and 2012. Among them, 23 patients had CushingPS, 56 had other paraneoplastic syndrome (OtherPS), and 304 had no paraneoplastic syndrome (NoPS). mong lung cancers, the proportion of small-cell lung can- Results: After comparison of the three groups, we observed that 1–5 Acers (SCLC) has decreased over the last 30 years, falling CushingPS patients had more extensive disease: 82.6% versus from 17.26% to 12.95% between 1986 and 2002 in the United 67.8% versus 53.3% (p = 0.005), respectively, with more than two 2 States. In our institution, it has dropped from 22.5% of all lung metastatic sites: 63.2% versus 15.8% and 24.1% (p ≤ 0.001), a higher cancers in 1982 to

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Apr 1, 2014

References

  • Small cell lung cancer in elderly patients: a review
    Owonikoko
  • Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database
    Govindan
  • Small cell lung cancer: state of the art and future perspectives
    Stupp
  • [Small-cell lung cancer] (Article in French)
    Barlesi
  • Small cell lung cancer
    Rosti
  • Symptom assessment in relapsed small cell lung cancer: cross-validation of the patient symptom assessment in lung cancer instrument
    Chen
  • Outcomes in recurrent small-cell lung cancer after one to four chemotherapy lines: a retrospective study of 300 patients
    Nagy-Mignotte
  • Outcomes of small-cell lung cancer patients treated with second-line chemotherapy: a multi-institutional retrospective analysis
    Garassino
  • A systematic analysis of efficacy of second-line chemotherapy in sensitive and refractory small-cell lung cancer
    Owonikoko
  • Cushing's syndrome due to ectopic corticotropin secretion: twenty years' experience at the National Institutes of Health
    Ilias
  • [Paraneoplastic Cushing's syndrome and small cell bronchial carcinoma] (Review, in French)
    Mennecier
  • Cushing's syndrome associated with ectopic corticotropin production and small-cell lung cancer
    Shepherd
  • Small cell lung cancer
    Sher
  • Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion: the University of Texas MD Anderson Cancer Center Experience
    Ejaz
  • Paraneoplasic Cushing's syndrome as an adverse prognostic factor in patients who die early with small cell lung cancer
    Dimopoulos
  • Ectopic corticotropin syndrome and small-cell carcinoma of the lung, clinical features, outcome, and complications
    Delisle
  • [Cushing syndrome and small cell carcinoma. Three case reports] (Article in French)
    de Lamberterie
  • Charlson comorbidity index as a predictor of outcomes in incident peritoneal dialysis patients
    Fried
  • The International Histological Classification of Tumours
    Sobin
  • Nouvelles recommandations pour l′évaluation de la réponse tumorale dans les tumeurs solides
    Duffaud
  • Bronchopulmonary neuroendocrine tumors
    Gustafsson
  • The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states (Review)
    Newell-Price
  • Paraneoplastic syndromes: an approach to diagnosis and treatment
    Pelosof
  • Ectopic corticotropin-releasing hormone (CRH) syndrome from metastatic small cell carcinoma: a case report and review of the literature
    Shahani
  • Cortisolemic indices predict severe infections in Cushing syndrome due to ectopic production of adrenocorticotropin
    Sarlis
  • Management of patients with small cell carcinoma and the syndrome of ectopic corticotropin secretion
    Collichio
  • Le défi diagnostic du syndrome de Cushing. [Cushing's syndrome: a diagnostic challenge]
    Faure
  • [Supportive cares on thoracic oncology] (Article in French)
    Rousseau-Bussac
  • Early palliative care for patients with metastatic non-small-cell lung cancer
    Temel
  • Does palliative care improve outcomes for patients with incurable illness? A review of the evidence
    El-Jawahri
  • Early palliative care in advanced lung cancer: a qualitative study
    Yoong
  • Early palliative care and metastatic non-small cell lung cancer: potential mechanisms of prolonged survival
    Irwin
  • Symptom improvement as prognostic factor for survival in cancer patients undergoing palliative care: a pilot study
    Narducci
  • The effect on survival of continuing chemotherapy to near death
    Saito
  • Palliative care in poor-performance status small cell lung cancer patients: is there a mandatory role for chemotherapy?
    Baldotto