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Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections

Programmed death 1: a critical regulator of T-cell function and a strong target for... Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections a,b,c a,b,c a,b,c a,d Lydie Trautmann , Elias A. Said , Rabih Halwani , Loury Janbazian , a,b,c a,b,c a,b,c Nicolas Chomont , Mohamed El-Far , Gae ¨ lle Breton , a,b,c,d a,b,c,d Elias K. Haddad and Rafick-Pierre Sekaly Purpose of review Abbreviations The intricate balance between positive and negative signals APC antigen-presenting cells delivered by accessory molecules is crucial to generate HCV hepatitis C virus HSV herpes simplex virus efficient immune responses while maintaining tolerance and ITSM immunoreceptor tyrosine-based switch motif preventing autoimmunity. Of these molecules, programmed LCMV lymphocytic choriomeningitis virus SHP Src homology region 2 domain-containing phosphatase death 1 has been described as a negative regulator of T-cell TCR T-cell receptor activation. This review will focus on current knowledge about PD-1 regulation in different diseases and discuss its potential 2007 Lippincott Williams & Wilkins benefits for the development of novel immune therapies. 1746-630X Recent findings PD-1 has recently been shown to be upregulated on HIV- specific CD8 T cells, whereas the PD-1 expression level Introduction was significantly correlated with viral load. Blockade of the The ‘two-signal’ model governs http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections

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ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e3280ebb5c9
pmid
19372890
Publisher site
See Article on Publisher Site

Abstract

Programmed death 1: a critical regulator of T-cell function and a strong target for immunotherapies for chronic viral infections a,b,c a,b,c a,b,c a,d Lydie Trautmann , Elias A. Said , Rabih Halwani , Loury Janbazian , a,b,c a,b,c a,b,c Nicolas Chomont , Mohamed El-Far , Gae ¨ lle Breton , a,b,c,d a,b,c,d Elias K. Haddad and Rafick-Pierre Sekaly Purpose of review Abbreviations The intricate balance between positive and negative signals APC antigen-presenting cells delivered by accessory molecules is crucial to generate HCV hepatitis C virus HSV herpes simplex virus efficient immune responses while maintaining tolerance and ITSM immunoreceptor tyrosine-based switch motif preventing autoimmunity. Of these molecules, programmed LCMV lymphocytic choriomeningitis virus SHP Src homology region 2 domain-containing phosphatase death 1 has been described as a negative regulator of T-cell TCR T-cell receptor activation. This review will focus on current knowledge about PD-1 regulation in different diseases and discuss its potential 2007 Lippincott Williams & Wilkins benefits for the development of novel immune therapies. 1746-630X Recent findings PD-1 has recently been shown to be upregulated on HIV- specific CD8 T cells, whereas the PD-1 expression level Introduction was significantly correlated with viral load. Blockade of the The ‘two-signal’ model governs

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: May 1, 2007

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