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ORIGINAL ARTICLE Reclassification of Neuroendocrine Tumors Improves the Separation of Carcinoids and the Prediction of Survival Birgit Guldhammer Skov, MD, DrMSci,* Mark Krasnik, MD,† Sylvie Lantuejoul, MD, PhD,‡ Torsten Skov, MD, PhD,§ and Elisabeth Brambilla, MD, PhD‡ he classification of neuroendocrine lung tumors (NE tu- Introduction: The classification of neuroendocrine lung tumors has 1–3 Tmor) has changed over the last decades. The present changed over the last decades. Reliable diagnoses are crucial for the World Health Organization (WHO) classification based on a quality of clinical databases. The purpose of this study is to deter- study by Travis et al. includes typical carcinoid (TC), atyp- mine to which extent the use of different diagnostic criteria of ical carcinoid (AC), large cell neuroendocrine carcinoma neuroendocrine lung tumors has influenced the classification of (LCNEC), and small cell lung carcinoma (SCLC). these tumors. The prognostic information of tumor, node, metastasis The tumor, node, metastasis (TNM) classification descriptors was also evaluated. has traditionally not been regarded as applicable to these Methods: We retrieved 110 tumors from the period 1989 to 2007. tumors and the value of TNM staging in relation to All tumors were reclassified according to the World Health Orga- survival of these
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Dec 1, 2008
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