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Role of Comorbidity on Survival after Radiotherapy and Chemotherapy for Nonsurgically Treated Lung Cancer

Role of Comorbidity on Survival after Radiotherapy and Chemotherapy for Nonsurgically Treated... ORIGINAL ARTICLE Role of Comorbidity on Survival after Radiotherapy and  Chemotherapy for Nonsurgically Treated Lung Cancer Anders Mellemgaard, MD, PhD,* Margreet Lüchtenborg, MSc, PhD,† Maria Iachina, PhD,‡ Erik Jakobsen, MD, MPH,‡ Anders Green, MD, PhD,‡ Mark Krasnik,§ and Henrik Møller, DrMedSci† When grouped by the three types of cancer treatment or no treatment, Background: Comorbidity, such as diseases of the cardiovascular, there was no influence of comorbidity on radiation therapy and mod- pulmonary, and other systems, may influence prognosis in lung can- est influence on survival after chemotherapy and chemoradiation. In cer and complicate its treatment. The performance status of patients, contrast, age remained a strong negative prognosticator after multi- which is a known prognostic marker, may also be influenced by variate adjustment as did stage and performance status. comorbidity. Due to the close link between tobacco smoking and Conclusion: Comorbidity has a limited effect on survival and only lung cancer, and because lung cancer is often diagnosed in advanced for patients treated with chemotherapy. It is rather the performance of ages (median age at diagnosis in Denmark is 70 years), comorbidity the patient at diagnosis than the medical history that prognosticates is present in a large proportion of lung cancer patients. survival in this patient group. Methods: Patients with any http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Role of Comorbidity on Survival after Radiotherapy and Chemotherapy for Nonsurgically Treated Lung Cancer

Mø ller, Henrik
Journal of Thoracic Oncology , Volume 10 (2) – Feb 1, 2015
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Copyright
Copyright © 2014 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
DOI
10.1097/JTO.0000000000000416
pmid
25371078
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Role of Comorbidity on Survival after Radiotherapy and  Chemotherapy for Nonsurgically Treated Lung Cancer Anders Mellemgaard, MD, PhD,* Margreet Lüchtenborg, MSc, PhD,† Maria Iachina, PhD,‡ Erik Jakobsen, MD, MPH,‡ Anders Green, MD, PhD,‡ Mark Krasnik,§ and Henrik Møller, DrMedSci† When grouped by the three types of cancer treatment or no treatment, Background: Comorbidity, such as diseases of the cardiovascular, there was no influence of comorbidity on radiation therapy and mod- pulmonary, and other systems, may influence prognosis in lung can- est influence on survival after chemotherapy and chemoradiation. In cer and complicate its treatment. The performance status of patients, contrast, age remained a strong negative prognosticator after multi- which is a known prognostic marker, may also be influenced by variate adjustment as did stage and performance status. comorbidity. Due to the close link between tobacco smoking and Conclusion: Comorbidity has a limited effect on survival and only lung cancer, and because lung cancer is often diagnosed in advanced for patients treated with chemotherapy. It is rather the performance of ages (median age at diagnosis in Denmark is 70 years), comorbidity the patient at diagnosis than the medical history that prognosticates is present in a large proportion of lung cancer patients. survival in this patient group. Methods: Patients with any

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Feb 1, 2015

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