Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Standard chemoradiation for glioblastoma results in progressive brain volume loss

Standard chemoradiation for glioblastoma results in progressive brain volume loss Standard chemoradiation for glioblastoma results in progressive brain volume loss Morgan J. Prust, MD ABSTRACT Kourosh Jafari-Khouzani, Objective: To investigate the effects of chemotherapy and cranial irradiation on normal brain PhD tissue using in vivo neuroimaging in patients with glioblastoma. Jayashree Kalpathy- Methods: We used longitudinal MRI to monitor structural brain changes during standard treat- Cramer, PhD ment in patients newly diagnosed with glioblastoma. We assessed volumetric and diffusion tensor Pavlina Polaskova, MD imaging measures in 14 patients receiving 6 weeks of chemoradiation, followed by up to 6 months Tracy T. Batchelor, MD of temozolomide chemotherapy alone. We examined changes in whole brain, gray matter (GM), Elizabeth R. Gerstner, white matter (WM), anterior lateral ventricle, and hippocampal volumes. Normal-appearing GM, MD WM, and hippocampal analyses were conducted within the hemisphere of lowest/absent tumor Jorg Dietrich, MD, PhD burden. We examined diffusion tensor imaging measures within the subventricular zone. Results: Whole brain (F 5 2.41; p 5 0.016) and GM (F 5 2.13; p 5 0.036) volume decreased during treatment, without significant WM volume change. Anterior lateral ventricle volume Correspondence to Dr. Dietrich: increased significantly (F 5 65.51; p , 0.001). In participants analyzed beyond 23 weeks, mean dietrich.jorg@mgh.harvard.edu ventricular http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurology Wolters Kluwer Health

Standard chemoradiation for glioblastoma results in progressive brain volume loss

Neurology , Volume 85 (8) – Aug 1, 2015

Loading next page...
 
/lp/wolters-kluwer-health/standard-chemoradiation-for-glioblastoma-results-in-progressive-brain-qMl0Z9fKPP

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Copyright
© 2015 American Academy of Neurology
ISSN
0028-3878
eISSN
1526-632X
DOI
10.1212/WNL.0000000000001861
pmid
26208964
Publisher site
See Article on Publisher Site

Abstract

Standard chemoradiation for glioblastoma results in progressive brain volume loss Morgan J. Prust, MD ABSTRACT Kourosh Jafari-Khouzani, Objective: To investigate the effects of chemotherapy and cranial irradiation on normal brain PhD tissue using in vivo neuroimaging in patients with glioblastoma. Jayashree Kalpathy- Methods: We used longitudinal MRI to monitor structural brain changes during standard treat- Cramer, PhD ment in patients newly diagnosed with glioblastoma. We assessed volumetric and diffusion tensor Pavlina Polaskova, MD imaging measures in 14 patients receiving 6 weeks of chemoradiation, followed by up to 6 months Tracy T. Batchelor, MD of temozolomide chemotherapy alone. We examined changes in whole brain, gray matter (GM), Elizabeth R. Gerstner, white matter (WM), anterior lateral ventricle, and hippocampal volumes. Normal-appearing GM, MD WM, and hippocampal analyses were conducted within the hemisphere of lowest/absent tumor Jorg Dietrich, MD, PhD burden. We examined diffusion tensor imaging measures within the subventricular zone. Results: Whole brain (F 5 2.41; p 5 0.016) and GM (F 5 2.13; p 5 0.036) volume decreased during treatment, without significant WM volume change. Anterior lateral ventricle volume Correspondence to Dr. Dietrich: increased significantly (F 5 65.51; p , 0.001). In participants analyzed beyond 23 weeks, mean dietrich.jorg@mgh.harvard.edu ventricular

Journal

NeurologyWolters Kluwer Health

Published: Aug 1, 2015

There are no references for this article.