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Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma

Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma ORIGINAL ARTICLE Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma Yoichi Ohtaki, MD,*†‡ Genichiro Ishii, MD, PhD,* Kanji Nagai, MD, PhD,† Satoshi Ashimine, MD,* Takeshi Kuwata, MD,* Tomoyuki Hishida, MD, PhD,† Mitsuyo Nishimura, MD, PhD,† Junji Yoshida, MD, PhD,† Izumi Takeyoshi, MD, PhD,‡ and Atsushi Ochiai, MD, PhD* of M2 macrophages, were significantly correlated with the numbers Background: Tumor tissue is composed of variable numbers of of CD204-positive macrophages (p  0.031 and p  0.031, respec- cancer cells and stromal cells, and tumor-associated macrophages tively). are recruited into cancer-induced stroma and produce a specific Conclusion: These findings demonstrated that CD204-positive mac- microenvironment. Alternatively, activated macrophages (M2 phe- rophages clearly reflect the tumor-promoting phenotype of tumor- notype) are known to be related to tumor progression and outcome, associated macrophages in lung adenocarcinoma. and CD204 has been reported to be expressed in M2 macrophages in Key Words: Macrophage, Tumor-associated macrophages (TAMs), some tumors. Lung cancer, Stroma, CD204. Methods: To investigate whether CD204-positive macrophages reflect tumor aggressiveness in adenocarcinoma of the lung, we (J Thorac Oncol. 2010;5: 1507–1515) investigated the relationships between the numbers of CD204- positive stromal macrophages and both clinicopathological features and outcome in 170 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma

Ochiai, Atsushi
Journal of Thoracic Oncology , Volume 5 (10) – Oct 1, 2010
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ISSN
1556-0864
DOI
10.1097/JTO.0b013e3181eba692
pmid
20802348
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma Yoichi Ohtaki, MD,*†‡ Genichiro Ishii, MD, PhD,* Kanji Nagai, MD, PhD,† Satoshi Ashimine, MD,* Takeshi Kuwata, MD,* Tomoyuki Hishida, MD, PhD,† Mitsuyo Nishimura, MD, PhD,† Junji Yoshida, MD, PhD,† Izumi Takeyoshi, MD, PhD,‡ and Atsushi Ochiai, MD, PhD* of M2 macrophages, were significantly correlated with the numbers Background: Tumor tissue is composed of variable numbers of of CD204-positive macrophages (p  0.031 and p  0.031, respec- cancer cells and stromal cells, and tumor-associated macrophages tively). are recruited into cancer-induced stroma and produce a specific Conclusion: These findings demonstrated that CD204-positive mac- microenvironment. Alternatively, activated macrophages (M2 phe- rophages clearly reflect the tumor-promoting phenotype of tumor- notype) are known to be related to tumor progression and outcome, associated macrophages in lung adenocarcinoma. and CD204 has been reported to be expressed in M2 macrophages in Key Words: Macrophage, Tumor-associated macrophages (TAMs), some tumors. Lung cancer, Stroma, CD204. Methods: To investigate whether CD204-positive macrophages reflect tumor aggressiveness in adenocarcinoma of the lung, we (J Thorac Oncol. 2010;5: 1507–1515) investigated the relationships between the numbers of CD204- positive stromal macrophages and both clinicopathological features and outcome in 170

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Oct 1, 2010

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