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Surgical Treatment and Prognosis of Primitive Neuroectodermal Tumors of the Thorax

Surgical Treatment and Prognosis of Primitive Neuroectodermal Tumors of the Thorax ORIGINAL ARTICLE Surgical Treatment and Prognosis of Primitive Neuroectodermal Tumors of the Thorax Adalet Demir, MD,* Mehmet Zeki Gunluoglu, MD,* Nergiz Dagoglu, MD,† Akif Turna, MD, FETCS, PhD,* Yavuz Dizdar, MD,† Kamil Kaynak, MD, FETCS,‡ Sukru Dilege, MD,‡ Nil Molinas Mandel, MD,§ Dilek Yilmazbayhan, MD, Seyyit Ibrahim Dincer, MD,* and Atilla Gurses, MD* involving the costovertebral junction had a 14% 1-year progression- Introduction: Primitive neuroectodermal tumors (PNETs) are rare, free survival (p  0.004). rapidly progressive, small- round cell tumors with a poor prognosis Conclusions: PNET is an aggressive malignancy that often requires despite multimodal therapy, including surgery and chemoradiother- multimodal therapy. Induction chemotherapy leads to a greater apy. The treatment of choice was unknown since no clinical series complete resection rate and better disease-free survival, while in- with surgical therapy had been reported. We evaluated the impact of volvement of the costovertebral junction indicates a poorer survival. multimodal treatment in patients with PNETs located in the thoracic Key Words: PNET, Chest, Multimodal therapy and lung. region. Methods: Between 1998 and 2006, 25 patients with PNETs in the (J Thorac Oncol. 2009;4: 185–192) thoracic region were treated in 3 tertiary-care hospitals. The patients consisted of 15 males and 10 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Surgical Treatment and Prognosis of Primitive Neuroectodermal Tumors of the Thorax

Gurses, Atilla
Journal of Thoracic Oncology , Volume 4 (2) – Feb 1, 2009
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References (19)

ISSN
1556-0864
DOI
10.1097/JTO.0b013e318194fafe
pmid
19179894
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Surgical Treatment and Prognosis of Primitive Neuroectodermal Tumors of the Thorax Adalet Demir, MD,* Mehmet Zeki Gunluoglu, MD,* Nergiz Dagoglu, MD,† Akif Turna, MD, FETCS, PhD,* Yavuz Dizdar, MD,† Kamil Kaynak, MD, FETCS,‡ Sukru Dilege, MD,‡ Nil Molinas Mandel, MD,§ Dilek Yilmazbayhan, MD, Seyyit Ibrahim Dincer, MD,* and Atilla Gurses, MD* involving the costovertebral junction had a 14% 1-year progression- Introduction: Primitive neuroectodermal tumors (PNETs) are rare, free survival (p  0.004). rapidly progressive, small- round cell tumors with a poor prognosis Conclusions: PNET is an aggressive malignancy that often requires despite multimodal therapy, including surgery and chemoradiother- multimodal therapy. Induction chemotherapy leads to a greater apy. The treatment of choice was unknown since no clinical series complete resection rate and better disease-free survival, while in- with surgical therapy had been reported. We evaluated the impact of volvement of the costovertebral junction indicates a poorer survival. multimodal treatment in patients with PNETs located in the thoracic Key Words: PNET, Chest, Multimodal therapy and lung. region. Methods: Between 1998 and 2006, 25 patients with PNETs in the (J Thorac Oncol. 2009;4: 185–192) thoracic region were treated in 3 tertiary-care hospitals. The patients consisted of 15 males and 10

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Feb 1, 2009

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