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Original Atricle Telomere Length and Recurrence Risk after Curative Resection in Patients with Early-Stage Non–Small-Cell Lung Cancer A Prospective Cohort Study Eric S. Kim, MD,*† Yuanqing Ye, PhD,‡ Ara A. Vaporciyan, MD,§ Jinliang Xing, MD, PhD,‡ Maosheng Huang, MD,‡ Jian Gu, PhD,‡ Jack A. Roth, MD,§ Scott M. Lippman, MD,*║ and Xifeng Wu, MD, PhD‡ Conclusions: This is the first prospective study to suggest that long Background: We hypothesized that telomere length in peripheral RTL is associated with recurrence in early stage NSCLC after cura- blood would have significant predictive value for risk of recurrence tive resection. Women and adenocarcinoma seem to be special sub- after curative resection in non–small-cell lung cancer (NSCLC). groups in which telomere biology may play an important role. Methods: This prospective study included 473 patients with histolog- ically confirmed early stage NSCLC who underwent curative therapy Key Words: Telomere, Telomere length, Telomerase, Early stage at MD Anderson Cancer Center between 1995 and 2008. Relative lung cancer, Non–small-cell lung cancer. telomere length (RTL) of peripheral leukocytes was measured by real- (J Thorac Oncol. 2015;10: 302–308) time polymerase chain reaction. The risk of recurrence was estimated as hazard ratios (HRs) and 95% confidence intervals (CIs) using a multivariable Cox proportional hazard regression model. ung cancer is the leading
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Feb 1, 2015
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