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Terameprocol (Tetra- O

Terameprocol (Tetra- O ORIGINAL ARTICLE Terameprocol (Tetra-O-Methyl Nordihydroguaiaretic Acid), an Inhibitor of Sp1-Mediated Survivin Transcription, Induces Radiosensitization in Non-small Cell Lung Carcinoma Yunguang Sun, PhD, Nicholas J. Giacalone, BS, and Bo Lu, MD, PhD locally advanced NSCLC. The efficacy of radiotherapy, how- Introduction: Survivin, an inhibitor of apoptosis protein and key ever, is hindered partly by defects in the apoptotic machinery regulator of mitosis, is up-regulated in a variety of cancers and is of cancer cells. Mechanisms of apoptosis, therefore, have often associated with a worse prognosis. Terameprocol down-regu- become promising targets for the development of novel lates the Sp1-mediated transcription of survivin and Cdk1, which is therapeutic agents that enhance radiation-induced cell death important for cell cycle progression and many other proteins. Sur- and lead to improved clinical outcomes. vivin inhibition has previously been shown to result in the induction Apoptosis, or programmed cell death, involves the of apoptosis and radiosensitization. release of caspase proteases from the mitochondria and is Methods: This study examined the effects of terameprocol admin- regulated by members of the Bcl-2 proteins family and the istration on survivin transcription and expression in HCC2429 and inhibitor of apoptosis proteins (IAPs) family. At 16.5-kDa, H460 lung cancer cells. We http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Terameprocol (Tetra- O

Lu, Bo
Journal of Thoracic Oncology , Volume 6 (1) – Jan 1, 2011
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ISSN
1556-0864
DOI
10.1097/JTO.0b013e3181fa646a
pmid
21107289
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Terameprocol (Tetra-O-Methyl Nordihydroguaiaretic Acid), an Inhibitor of Sp1-Mediated Survivin Transcription, Induces Radiosensitization in Non-small Cell Lung Carcinoma Yunguang Sun, PhD, Nicholas J. Giacalone, BS, and Bo Lu, MD, PhD locally advanced NSCLC. The efficacy of radiotherapy, how- Introduction: Survivin, an inhibitor of apoptosis protein and key ever, is hindered partly by defects in the apoptotic machinery regulator of mitosis, is up-regulated in a variety of cancers and is of cancer cells. Mechanisms of apoptosis, therefore, have often associated with a worse prognosis. Terameprocol down-regu- become promising targets for the development of novel lates the Sp1-mediated transcription of survivin and Cdk1, which is therapeutic agents that enhance radiation-induced cell death important for cell cycle progression and many other proteins. Sur- and lead to improved clinical outcomes. vivin inhibition has previously been shown to result in the induction Apoptosis, or programmed cell death, involves the of apoptosis and radiosensitization. release of caspase proteases from the mitochondria and is Methods: This study examined the effects of terameprocol admin- regulated by members of the Bcl-2 proteins family and the istration on survivin transcription and expression in HCC2429 and inhibitor of apoptosis proteins (IAPs) family. At 16.5-kDa, H460 lung cancer cells. We

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Jan 1, 2011

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