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The CXCR4/SDF-1 Chemokine Receptor Axis A New Target Therapeutic for Non-small Cell Lung Cancer

The CXCR4/SDF-1 Chemokine Receptor Axis A New Target Therapeutic for Non-small Cell Lung Cancer PATHWAY OF THE MONTH The CXCR4/SDF-1 Chemokine Receptor Axis A New Target Therapeutic for Non-small Cell Lung Cancer Shannon Otsuka, BSc, and Gwyn Bebb, BMBCh, PhD, FRCPC Chemokines, a class of small (8 –14 kDa) proinflam- Abstract: Chemokines are proinflammatory chemoattractant cyto- matory chemoattractant cytokines, are the major regulators kines that regulate cell trafficking and adhesion. The CXCR4 che- of cell trafficking and adhesion in the body. Chemokines mokine receptor and its ligand, stromal cell derived factor (SDF-1), bind and activate a subset of seven transmembrane spanning constitute a chemokine/receptor axis that has attracted great interest G protein coupled receptors present on the surface of target because of an increasing understanding of its role in cancer, includ- cells. They play a crucial role in the host immune defense ing lung cancer. The CXCR4/SDF-1 complex activates several system by recruiting specific leukocyte subpopulations to pathways that mediate chemotaxis, migration and secretion of an- sites of tissue damage and infection, and are highly up- giopoietic factors. Neutralization of SDF-1 by anti-SDF-1 or anti- regulated by inflammatory stimuli such as antigens, poly- 4,5 CXCR4 monoclonal antibody in preclinical in vivo studies results in clonal stimulants, cell irritants, and cytokines. Chemokines a significant http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

The CXCR4/SDF-1 Chemokine Receptor Axis A New Target Therapeutic for Non-small Cell Lung Cancer

Bebb, Gwyn
Journal of Thoracic Oncology , Volume 3 (12) – Dec 1, 2008
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ISSN
1556-0864
DOI
10.1097/JTO.0b013e31818dda9d
pmid
19057260
Publisher site
See Article on Publisher Site

Abstract

PATHWAY OF THE MONTH The CXCR4/SDF-1 Chemokine Receptor Axis A New Target Therapeutic for Non-small Cell Lung Cancer Shannon Otsuka, BSc, and Gwyn Bebb, BMBCh, PhD, FRCPC Chemokines, a class of small (8 –14 kDa) proinflam- Abstract: Chemokines are proinflammatory chemoattractant cyto- matory chemoattractant cytokines, are the major regulators kines that regulate cell trafficking and adhesion. The CXCR4 che- of cell trafficking and adhesion in the body. Chemokines mokine receptor and its ligand, stromal cell derived factor (SDF-1), bind and activate a subset of seven transmembrane spanning constitute a chemokine/receptor axis that has attracted great interest G protein coupled receptors present on the surface of target because of an increasing understanding of its role in cancer, includ- cells. They play a crucial role in the host immune defense ing lung cancer. The CXCR4/SDF-1 complex activates several system by recruiting specific leukocyte subpopulations to pathways that mediate chemotaxis, migration and secretion of an- sites of tissue damage and infection, and are highly up- giopoietic factors. Neutralization of SDF-1 by anti-SDF-1 or anti- regulated by inflammatory stimuli such as antigens, poly- 4,5 CXCR4 monoclonal antibody in preclinical in vivo studies results in clonal stimulants, cell irritants, and cytokines. Chemokines a significant

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Dec 1, 2008

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