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ORIGINAL ARTICLE The Impact of Thymoma Histotype on Prognosis in a Worldwide Database Cleo-Aron Weis, MD, MSc,*Xiaopan Yao, PhD,† Yanhong Deng, MPH,† Frank C. Detterbeck, MD,‡ Mirella Marino, MD,§ Andrew G. Nicholson, MD,║ James Huang, MD,¶ Philipp Ströbel, MD,# Alberto Antonicelli, MD,‡ and Alexander Marx, MD,* for the Contributors to the ITMIG Retrospective Database stage and histology, the latter partially limited to early stage disease, Introduction: The rarity of thymomas and lack of multi-institutional on recurrence. studies have hampered therapeutic progress for decades. To overcome this, the members of the International Thymic Malignancy Interest Key Words: Thymoma, International Thymic Malignancy Interest Group created a worldwide retrospective database. This database was Group, World Health Organization histotype, Prognosis, Epidemiology. analyzed regarding the demographic and geographic distribution of thy- (J Thorac Oncol. 2015;10: 367–372) momas and the impact of different variables on survival and recurrence. Methods: This study analyzed 4221 thymomas diagnosed between 1983 and 2012 with World Health Organization histotype infor- hymomas and thymic carcinomas (TCs) are epithelial mation from the International Thymic Malignancy Interest Group Ttumors of the thymus. They are the most frequent tumors database. Associations to survival and recurrence were studied by of the anterior mediastinum in adults but account for less than univariate and multivariate analyses.
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Feb 1, 2015
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