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The potential role of epitope-specific T-cell receptor diversity in the control of HIV replication

The potential role of epitope-specific T-cell receptor diversity in the control of HIV replication The potential role of epitope-specific T-cell receptor diversity in the control of HIV replication a a,b Brenna C. Simons and Spyros A. Kalams Abbreviations Purpose of review The purpose of this review is to assess the influence of CDR complementarity determining region CTL cytotoxic T lymphocyte T-cell receptor clonotype diversity on the recognition and EBV Epstein – Barr virus control of chronic viral infections, and specifically in the HLA human leukocyte antigen HSV herpes simplex virus case of HIV infection. LCMV lymphocytic choriomeningitis virus Recent findings TCR T-cell receptor TRBV T-cell receptor b-chain V region The latest publications have examined the role of T-cell receptor repertoires specific for dominant epitopes in the ability to recognize variants and control viremia in chronic 2007 Lippincott Williams & Wilkins 1746-630X viral infections. In the hepatitis C virus and SIV models, diverse T-cell receptor repertoires appear to limit immune escape. In HIV infection, circulating clonotypes may have Introduction different functional abilities, showing another potential The immune T-cell receptor (TCR) repertoire directed advantage of diverse clonotypic repertoires. A recent study against a peptide major histocompatibility complex suggests that at times narrow repertoires against a (MHC) is the sum of individually rearranged TCRs. conserved epitope http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

The potential role of epitope-specific T-cell receptor diversity in the control of HIV replication

Kalams, Spyros A
Current Opinion in HIV and Aids , Volume 2 (3) – May 1, 2007
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ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e3280ef692f
pmid
19372884
Publisher site
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Abstract

The potential role of epitope-specific T-cell receptor diversity in the control of HIV replication a a,b Brenna C. Simons and Spyros A. Kalams Abbreviations Purpose of review The purpose of this review is to assess the influence of CDR complementarity determining region CTL cytotoxic T lymphocyte T-cell receptor clonotype diversity on the recognition and EBV Epstein – Barr virus control of chronic viral infections, and specifically in the HLA human leukocyte antigen HSV herpes simplex virus case of HIV infection. LCMV lymphocytic choriomeningitis virus Recent findings TCR T-cell receptor TRBV T-cell receptor b-chain V region The latest publications have examined the role of T-cell receptor repertoires specific for dominant epitopes in the ability to recognize variants and control viremia in chronic 2007 Lippincott Williams & Wilkins 1746-630X viral infections. In the hepatitis C virus and SIV models, diverse T-cell receptor repertoires appear to limit immune escape. In HIV infection, circulating clonotypes may have Introduction different functional abilities, showing another potential The immune T-cell receptor (TCR) repertoire directed advantage of diverse clonotypic repertoires. A recent study against a peptide major histocompatibility complex suggests that at times narrow repertoires against a (MHC) is the sum of individually rearranged TCRs. conserved epitope

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: May 1, 2007

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