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Treatment Modalities for T1N0 Esophageal Cancers A Comparative Analysis of Local Therapy Versus Surgical Resection

Treatment Modalities for T1N0 Esophageal Cancers A Comparative Analysis of Local Therapy Versus... ORIGINAL ARTICLE Treatment Modalities for T1N0 Esophageal Cancers A Comparative Analysis of Local Therapy Versus Surgical Resection Mark F. Berry, MD,* Josiane Zeyer-Brunner, MMed, MLaw,†‡ Anthony W. Castleberry, MD, MMCi,* Jeremiah T. Martin, MD,*§ Beat Gloor, MD,† Ricardo Pietrobon, MD, PhD,* Thomas A. D’Amico, MD,* and Mathias Worni, MD, MHS*† he prognosis for patients treated for intra- and submucosal Background:To investigate the role of nonsurgical treatment for Tesophageal cancers is significantly better than the prognosis early-stage esophageal cancer, we compared the outcomes of local for other patients found to have esophageal cancer, even those therapy to esophagectomy, using a large, national database. found in other relatively early-stage diseases. Historically, Methods:Five-year cancer-specific and overall survival (OS) of esophagectomy has been demonstrated to be oncologically patients, with T1N0M0 squamous cell or adenocarcinoma of the mid efficacious; however, despite improvement over time, surgery or distal esophagus treated with either surgery or local therapy, with is still associated with considerable morbidity and mortal- ablative and/or excision techniques, in the Surveillance Epidemiology 2–8 ity. Local treatments with modalities, such as endoscopic and End Results cancer registry from 1998 to 2008, were compared mucosal resection, radiofrequency ablation, cryotherapy, and using the Kaplan–Meier approach, and multivariable and propensity- photodynamic therapy have http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Treatment Modalities for T1N0 Esophageal Cancers A Comparative Analysis of Local Therapy Versus Surgical Resection

Worni, Mathias
Journal of Thoracic Oncology , Volume 8 (6) – Jun 1, 2013
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Copyright
Copyright © 2013 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
DOI
10.1097/JTO.0b013e3182897bf1
pmid
24614244
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Treatment Modalities for T1N0 Esophageal Cancers A Comparative Analysis of Local Therapy Versus Surgical Resection Mark F. Berry, MD,* Josiane Zeyer-Brunner, MMed, MLaw,†‡ Anthony W. Castleberry, MD, MMCi,* Jeremiah T. Martin, MD,*§ Beat Gloor, MD,† Ricardo Pietrobon, MD, PhD,* Thomas A. D’Amico, MD,* and Mathias Worni, MD, MHS*† he prognosis for patients treated for intra- and submucosal Background:To investigate the role of nonsurgical treatment for Tesophageal cancers is significantly better than the prognosis early-stage esophageal cancer, we compared the outcomes of local for other patients found to have esophageal cancer, even those therapy to esophagectomy, using a large, national database. found in other relatively early-stage diseases. Historically, Methods:Five-year cancer-specific and overall survival (OS) of esophagectomy has been demonstrated to be oncologically patients, with T1N0M0 squamous cell or adenocarcinoma of the mid efficacious; however, despite improvement over time, surgery or distal esophagus treated with either surgery or local therapy, with is still associated with considerable morbidity and mortal- ablative and/or excision techniques, in the Surveillance Epidemiology 2–8 ity. Local treatments with modalities, such as endoscopic and End Results cancer registry from 1998 to 2008, were compared mucosal resection, radiofrequency ablation, cryotherapy, and using the Kaplan–Meier approach, and multivariable and propensity- photodynamic therapy have

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Jun 1, 2013

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