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Virologic suppression in treatment-experienced patients after virologic rebound or failure of therapy a b c d Rui Sarmento-Castro , Carlos Vasconcelos , Maria Joa˜oAguas , Rui Marques and Joaquim Oliveira Infectious Diseases Service, Centro Hospitalar do Purpose of review Porto, ECS – University of Minho, Clinical To discuss factors related to virologic failure and review data from recent clinical trials Immunology Unit, Centro Hospitalar do Porto, ICBAS, Infectious Diseases Department (IDD) Hospital evaluating re-suppression of viremia in extensively-treated HIV-infected patients with d e Garcia de Orta, IDD Hospital de S. Joa˜o and IDD resistance. Hospitais da Universidade de Coimbra, and University of Coimbra, Portugal Recent findings Factors associated with virologic failure can be related to the virus (e.g. resistance), the Correspondence to Rui Sarmento-Castro, Infectious Diseases Service, Centro Hospitalar do Porto (Unidade patient (e.g. adherence) or HIV therapy (e.g. availability) and must be analyzed to Joaquim Urbano), Rua de Camara Pestana 348, minimize the likelihood of a new failure. Recent clinical trials have shown that it is now 4369-004, Porto, Portugal Tel: +351 225899550; fax: +351 225106160; possible to achieve virologic suppression in a large proportion of treatment-experienced e-mail: hju@hjurbano.min-saude.pt patients with extensive drug resistance, with several newer agents
Current Opinion in HIV and Aids – Wolters Kluwer Health
Published: Dec 1, 2011
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