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IASLC STAGING COMMITTEE ARTICLE Visceral Pleural Invasion: Pathologic Criteria and Use of Elastic Stains Proposal for the 7th Edition of the TNM Classification for Lung Cancer William D. Travis, MD,* Elisabeth Brambilla, MD,† Ramon Rami-Porta, MD,‡ Eric Vallie `res, MD,§ Masahiro Tsuboi, MD, Valerie Rusch, MD,¶ and Peter Goldstraw, FRCS#; on behalf of the International Staging Committee TNM. We also recommend that elastic stains be used in cases when Objective: To define the anatomic extent of visceral pleural inva- the distinction between PL0 and PL1 is not clear based on evaluation sion (VPI) and to assess whether elastic stains are useful to deter- of hematoxylin and eosin sections. mine VPI in lung cancer. The elastic layer of the visceral pleura is Key Words: Visceral pleural invasion, Lung cancer, Stage, Elastic not mentioned in the current International Union Against Cancer or stain, Pathology, Pleura. American Joint Committee on Cancer staging documents. Methods: A Pub Med search (www.pubmed.gov) of the National (J Thorac Oncol. 2008;3: 1384–1390) Library of Medicine was made for all articles published between 1970 and 2007 in humans under the search terms lung cancer and pleural invasion. These were reviewed for data regarding the patho- he anatomic extent
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Dec 1, 2008
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